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Comment
. 2021 Jan 15;27(2):374-376.
doi: 10.1158/1078-0432.CCR-20-3507. Epub 2020 Nov 13.

Senescent T Cells as a Resistance Mechanism to Lung Cancer Immunotherapy

Diego Salas-Benito  1 , Iñaki Eguren-Santamaria  1 , Miguel F Sanmamed  2   3   4   5
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Comment

Senescent T Cells as a Resistance Mechanism to Lung Cancer Immunotherapy

Diego Salas-Benito et al. Clin Cancer Res. .

Abstract

It has been reported that a group of patients with advanced non-small cell lung cancer showed circulating T cells with a senescent phenotype, and an abundance of such cells is associated with worse clinical response to immune checkpoint inhibitors. This study encourages further analysis of the role of senescent T cells in resistance to lung cancer immunotherapy.See related article by Ferrara et al., p. 492.

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References

    1. Ferrara R, Naigeon M, Auclin E, Duchemann B, Cassard L, Jouniaux JM, et al. Circulating T-cell immunosenescence in patients with advanced non-small cell lung cancer treated with single agent PD-1/PD-L1 inhibitors or platinum-based chemotherapy. Clin Cancer Res. 2021;27:492–503.
    1. Akbar AN, Henson SM, Lanna A. Senescence of T lymphocytes: implications for enhancing human immunity. Trends Immunol. 2016;37:866–76.
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    1. Thommen DS, Schumacher TN. T cell dysfunction in cancer. Cancer Cell. 2018;33:547–62.
    1. Zhao Y, Shao Q, Peng G. Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment. Cell Mol Immunol. 2020;17:27–35.

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