Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Apr;143(4):355-366.
doi: 10.1111/ane.13374. Epub 2020 Nov 27.

CTP-guided reperfusion therapy in acute ischemic stroke: a meta-analysis

Anubhav Katyal  1   2 , Sonu Bhaskar  1   2   3   4   5
Affiliations
Meta-Analysis

CTP-guided reperfusion therapy in acute ischemic stroke: a meta-analysis

Anubhav Katyal et al. Acta Neurol Scand. 2021 Apr.

Abstract

Background: Computed tomography perfusion (CTP) imaging could be useful in guiding reperfusion therapy or patient selection in acute ischemic stroke (AIS) patients. The aim of the current study was to determine the efficacy of the CTP-guided reperfusion therapy in AIS by performing a systematic review and meta-analysis.

Methods: Medline/PubMed, Embase, and the Cochrane library were searched using the terms: "CT perfusion", "acute stroke" and "reperfusion therapy". The following studies were included: (a) studies reporting original data; (b) patients aged 18 years or above; (c) patients diagnosed with anterior circulation AIS; and (d) studies with good methodological design.

Results: Twenty-two studies were finally included in the metanalysis with a total of 5, 687 patients. CTP-guided reperfusion therapy was associated with increased odds of good functional outcome without significant difference in safety profile.

Conclusions: CTP-guided reperfusion therapy improved functional outcomes in AIS, with increased benefits to patients treated with endovascular thrombectomy.

Keywords: CT perfusion; decision-making; ischemic stroke; patient selection; treatment.

PubMed Disclaimer

References

REFERENCES

    1. Feigin VL, Nichols E, Alam T, et al. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):459-480.
    1. Seshadri S, Beiser A, Kelly-Hayes M, et al. The lifetime risk of stroke. Stroke. 2006;37(2):345-350.
    1. Bhaskar S, Stanwell P, Cordato D, Attia J, Levi C. Reperfusion therapy in acute ischemic stroke: dawn of a new era? BMC Neurol. 2018;18(1):8.
    1. Powers William J, Rabinstein Alejandro A, Ackerson T, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418.
    1. Gabrielli A, Layon AJ, Yu M. Civetta, Taylor, & Kirby's Manual of Critical Care. Philadelphia, PA: Lippincott Williams & Wilkins; 2012.