Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2020 Sep-Oct;72(5):445-447.
doi: 10.1016/j.ihj.2020.07.014. Epub 2020 Jul 17.

Study of correlation between epicardial fat thickness and severity of coronary artery disease

Sunil Kumar Shambu  1 , Nagaraj Desai  2 , Nikhil Sundaresh  3 , M Suresh Babu  4 , B Madhu  5 , Oliver Joel Gona  6
Affiliations
Observational Study

Study of correlation between epicardial fat thickness and severity of coronary artery disease

Sunil Kumar Shambu et al. Indian Heart J. 2020 Sep-Oct.

Abstract

Epicardial fat thickness (EFT) reflects visceral adiposity and is associated with coronary artery disease (CAD). This study aimed to assess the correlation of echocardiographic EFT with the severity of CAD and to determine the EFT cut-off to predict CAD. EFT was measured in 503 patients undergoing coronary angiogram. Mean EFT was significantly higher in the CAD group than control group (5.55 ± 1.21 mm vs 3.25 ± 1.15 mm, p < 0.0001). EFT correlated with Gensini score (r = 0.906, p < 0.001). EFT cut-off ≥ 4.75 mm had 87% sensitivity and 63% specificity for prediction of significant CAD (AUC: 0.831, p < 0.001).

Keywords: Coronary artery disease; Echocardiography; Epicardial fat thickness; Gensini score.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest All authors have none to declare.

Figures

Fig. 1
Fig. 1
ROC curve of EFT for prediction of significant CAD.
See this image and copyright information in PMC

References

    1. Iacobellis G., Corradi D., Sharma A.M. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005 Oct;2(10):536–543. - PubMed
    1. Rabkin S.W. Epicardial fat: properties, function and relationship to obesity. Obes Rev. 2007 May;8(3):253–261. - PubMed
    1. Ahn S.G., Lim H.S., Joe D.Y. Relationship of epicardial adipose tissue by echocardiography to coronary artery disease. Heart. 2008 Mar 1;94(3):e7. - PubMed
    1. Meenakshi K., Rajendran M., Srikumar S., Chidambaram S. Epicardial fat thickness: a surrogate marker of coronary artery disease–Assessment by echocardiography. Indian Heart J. 2016 May 1;68(3):336–341. - PMC - PubMed
    1. Iacobellis G., Willens H.J. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr. 2009 Dec 1;22(12):1311–1319. - PubMed

Publication types