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Comment
. 2021 Apr;82(4):84-123.
doi: 10.1016/j.jinf.2020.11.009. Epub 2020 Nov 12.

SARS-CoV-2 detection by nasal strips: A superior tool for surveillance of paediatric population

Renee W Y Chan  1 , Kate C Chan  2 , Kathy Y Y Chan  2 , Grace C Y Lui  3 , Joseph G S Tsun  4 , Rity Y K Wong  3 , Michelle W L Yu  5 , Maggie H T Wang  6 , Paul K S Chan  7 , Hugh Simon Lam  2 , Albert M Li  8
Affiliations
Comment

SARS-CoV-2 detection by nasal strips: A superior tool for surveillance of paediatric population

Renee W Y Chan et al. J Infect. 2021 Apr.
No abstract available

Keywords: Deep throat saliva; Nasal strip; Paediatrics surveillance; SARS-CoV-2 surveillance; Sampling methods; Viral RNA detection.

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Figures

Fig 1
Fig. 1
Correlation, agreement and comparison of the cycle threshold (Ct) values from nasal strip, NPSTS and DTS, and the stability of nasal strip sample at room temperature. The correlation coefficients of NPSTS and DTS are superimposed on the panel with trend lines estimated using simple linear regression (Panel A). Plot shows the available Ct values of 31 samples which had positive test results from both tests. Data on three samples with negative result in both nasal strip and NPSTS, one sample with negative result in nasal strip but a positive result in NPSTS (Ct value = 35), one sample with negative result in both nasal strip and DTS, one sample with negative result from nasal strip but positive result in DTS, and six samples with positive result in nasal strip but negative result DTS were excluded from the Spearman correlation analysis. Bland-Altman Plots indicate the agreement of nasal strip versus NPSTS (Panel B) and DTS (Panel C), respectively. The differences between the two measurements are plotted against their average Ct values. Almost all observations are located within 2 standard deviations of the mean difference, and no bias is shown. The plots show that the nasal strip gives consistent and comparable measurements versus the NPSTS and DTS. SARS-CoV-2 RNA load in nasal strip and NPSTS (n = 21) (Panel D) and DTS (n = 22) (Panel E). Samples were obtained from 36 in-patients who had a diagnosis of COVID‐19. Panel A shows SARS‐CoV‐2 RNA Ct in the nasal strip and NPSTS; panel B shows SARS‐CoV‐2 RNA Ct in the nasal strip and DTS. The lines indicate samples from the same patient obtained within 24 hours. Negative result is arbitrarily set as Ct = 40 and results were compared with the use of a Wilcoxon signed‐rank test (p < 0.05). Panel F shows the stability of nasal strip samples for the detection of SARS-CoV-2 (n = 6). Comparison of Ct upon 24 (blue) and 72 (pink) hours RT storage from nasal strips directly lysed after sample collection.
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References

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