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Comparative Study
. 2021 Jan:102:375-380.
doi: 10.1016/j.ijid.2020.11.127. Epub 2020 Nov 12.

Systematically comparing COVID-19 with the 2009 influenza pandemic for hospitalized patients

Pengfei Li  1 , Yining Wang  1 , Maikel P Peppelenbosch  1 , Zhongren Ma  2 , Qiuwei Pan  3
Affiliations
Comparative Study

Systematically comparing COVID-19 with the 2009 influenza pandemic for hospitalized patients

Pengfei Li et al. Int J Infect Dis. 2021 Jan.

Abstract

Objectives: This study aimed to comprehensively compare the clinical features of hospitalized COVID-19 patients with hospitalized 2009 influenza pandemic patients.

Methods: Medline, Embase, Web of Science, Cochrane CENTRAL, and Google scholar were systematically searched to identify studies related to COVID-19 and the 2009 influenza pandemic. The pooled incidence rates of clinical features were estimated using the DerSimonian-Laird random-effects model with the Freeman-Tukey double arcsine transformation method.

Results: The incidence rates of fever, cough, shortness of breath, sore throat, rhinorrhea, myalgia/muscle pain, or vomiting were found to be significantly higher in influenza patients when compared with COVID-19 patients. The incidence rates of comorbidities, including cardiovascular disease/hypertension and diabetes, were significantly higher in COVID-19 compared with influenza patients. In contrast, comorbidities such as asthma, chronic obstructive pulmonary disease, and immunocompromised conditions were significantly more common in influenza compared with COVID-19 patients. Unexpectedly, the estimated rates of intensive care unit admission, treatment with extracorporeal membrane oxygenation, treatment with antibiotics, and fatality were comparable between hospitalized COVID-19 and 2009 influenza pandemic patients.

Conclusions: This study comprehensively estimated the differences and similarities of the clinical features and burdens of hospitalized COVID-19 and 2009 influenza pandemic patients. This information will be important to better understand the current COVID-19 pandemic.

Keywords: 2009 influenza pandemic; COVID-19; Clinical features; Comorbidities; Meta-analysis; Symptoms.

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Figures

Figure 1
Figure 1
Study selection.
Figure 2
Figure 2
Forest plot of incidence rate of common symptoms in hospitalized COVID-19 and 2009 influenza pandemic patients.
Figure 3
Figure 3
Forest plot of incidence rate of comorbidities in hospitalized COVID-19 and 2009 influenza patients.
See this image and copyright information in PMC

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References

    1. Adhikari S.P., Meng S., Wu Y.J., Mao Y.P., Ye R.X., Wang Q.Z. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. 2020;9(1):29. - PMC - PubMed
    1. Gu J., Han B., Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020;158(6):1518–1519. - PMC - PubMed
    1. He D., Zhao S., Li Y., Cao P., Gao D., Lou Y. Comparing COVID-19 and the 1918-19 influenza pandemics in the United Kingdom. Int J Infect Dis. 2020;98:67–70. - PMC - PubMed
    1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. - PMC - PubMed
    1. Ji Y., Ma Z., Peppelenbosch M.P., Pan Q. Potential association between COVID-19 mortality and health-care resource availability. Lancet Glob Health. 2020;8(4):e480. - PMC - PubMed

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