Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021;11(1):304-306.
doi: 10.1016/j.jcmgh.2020.07.014. Epub 2020 Oct 22.

Confusion on Cell Fusion

Affiliations

Confusion on Cell Fusion

Rana Ramadan et al. Cell Mol Gastroenterol Hepatol. 2021.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Fusion or confusion in intestinal epithelium. Schematic representation of hypothetical cell fusion of intestinal cells with BMDCs and the confirmed mechanisms of repair because of intestinal plasticity. Intestinal epithelium is a tightly regulated and self-sustained tissue in homeostasis and disease. ISCs play a key role in maintaining the integrity of the intestinal layer. Differentiated cells, progenitors, and Paneth cells contribute to the regeneration of the crypt following damage. Cell fusion is therefore dispensible for the regeneration of the crypt.

Comment in

  • Rebuttal to: Confusion on Cell Fusion.
    Sutton TL, Walker BS, Wong MH. Sutton TL, et al. Cell Mol Gastroenterol Hepatol. 2021;11(1):307-308. doi: 10.1016/j.jcmgh.2020.09.018. Epub 2020 Oct 14. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33068772 Free PMC article. No abstract available.

References

    1. Álvarez-Dolado M., Martínez-Losa M. Cell fusion and tissue regeneration. Advances in Experimental Medicine and Biology Cell Fusion in Health and Disease. 2011:161–175. - PubMed
    1. Yamanaka S., Blau H.M. Nuclear reprogramming to a pluripotent state by three approaches. Nature. 2010;465:704–712. - PMC - PubMed
    1. Harris R.G. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science. 2004;305:90–93. - PubMed
    1. Barker N. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;499:1003–1007. - PubMed
    1. Sato T. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459:262–265. - PubMed

LinkOut - more resources