Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct 26:7:575449.
doi: 10.3389/fvets.2020.575449. eCollection 2020.

Autologous Platelet-Rich Plasma Enhances the Healing of Large Cutaneous Wounds in Dogs

Ilaria Iacopetti  1 , Marco Patruno  2 , Luca Melotti  2 , Tiziana Martinello  3 , Silvia Bedin  1 , Tamara Badon  1 , Edoardo Maria Righetto  4 , Anna Perazzi  1
Affiliations

Autologous Platelet-Rich Plasma Enhances the Healing of Large Cutaneous Wounds in Dogs

Ilaria Iacopetti et al. Front Vet Sci. .

Abstract

Platelet-rich plasma (PRP) is known to play a crucial role in skin wound healing, in both Human and Veterinary Medicine. Remarkably, until now, no studies have reported PRP treatment in subacute full-thickness skin wounds of the dog. The aim of this study was to evaluate the effects of two consecutive applications of autologous PRP, with the second application after 15 days, in 6 dogs showing large subacute skin wounds. The percentage of contraction, re-epithelialization and healing in all treated patients indicated that no complications or side effects, associated with consecutive PRP treatments, occurred in any patient and all wounds achieved complete closure and re-epithelialization. Our results suggest a positive effect of repeated autologous topical PRP treatments in large cutaneous subacute wounds of different etiology. Therefore, this PRP treatment could represent a simple, cost-effective, and valid alternative to promote healing processes in subacute large wounds cases in dogs.

Keywords: autologous platelet-rich plasma; cutaneous wound healing; dog; regenerative medicine; subacute wounds.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serial macroscopic images of the wound site of the six case at different time points (T0, T7, T15, T30). Treatments were applied after T0 e after T15. Case 4 was missing at the final 30 day follow up.
Figure 2
Figure 2
Percent of wound contraction, wound re-epithelialization, and wound healing measured weekly.
See this image and copyright information in PMC

References

    1. DeRossi R, Coelho ACAO, De Mello GS, Frazílio FO, Leal CRB, Facco GG, et al. . Effects of platelet-rich plasma gel on skin healing in surgical wound in horses. Acta Cir Bras. (2009) 24:276–81. 10.1590/S0102-86502009000400006 - DOI - PubMed
    1. Sardari K, Emami MR, Kazemi H, Movasagi AR, Goli AA, Lotfi A, et al. Effects of platelet-rich plasma (PRP) on cutaneous regeneration and wound healing in dogs treated with dexamethasone. Comp Clin Path. (2010) 20:155–62. 10.1007/s00580-010-0972-y - DOI
    1. Knox RL, Hunt AR, Collins JC, DeSmet M, Barnes S. Platelet-rich plasma combined with skin substitute for chronic wound healing: a case report. J Extra Corpor Technol. (2006) 38:260–4. - PMC - PubMed
    1. Dart AJ, Dowling BA, Smith CL. Topical treatments in equine wound management. Vet Clin Equine. (2005) 21:77–89. 10.1016/j.cveq.2004.11.003 - DOI - PubMed
    1. Theoret CL. The pathophysiology of wound repair. Vet Clin North Am Equine Pract. (2005) 21:1–13. 10.1016/j.cveq.2004.11.001 - DOI - PubMed