Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 22;2(9):acmi000157.
doi: 10.1099/acmi.0.000157. eCollection 2020.

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010-2019

Khadija Ait Mouss  1   2   3 , Aziza Razki  3 , Eva Hong  4 , Bahija Zaki  2 , Fakhreddine Maaloum  1   2 , Néhémie Nzoyikorera  1   2 , Houria Belabbes  1   2 , Naima Elmdaghri  2 , Khalid Zerouali  1   2
Affiliations

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010-2019

Khadija Ait Mouss et al. Access Microbiol. .

Abstract

Surveillance of invasive meningococcal diseases (IMD) must be carried out regularly and continuously in order to detect the emergence of strains of reduced susceptibility to antibiotics for therapeutic and prophylactic use and the appearance of new invasive clones. Molecular-typing approaches allow reliable traceability and powerful epidemiological analysis. This is an epidemiological study of Neisseria meningitidis causing meningitis in Casablanca, Morocco. The grouping was confirmed by PCR mainly on the isolates from cerebrospinal fluid (CSF). A total of 245 confirmed isolates of N .meningitidis were obtained between 2010 and 2019 of which 93 % are of group B. Overall, 24 % of all the isolates have a reduced susceptibility to penicillin G, but no resistance to penicillin G has been reported. All the isolated strains are susceptible to third-generation cephalosporins (3GCs). Genotyping by multilocus sequence typing (MLST) of a selection of 18 strains showed that the majority of isolates belong to the invasive clonal complex CC 32(9/18) followed by the CC 41/44(3/18).

Keywords: Neisseria meningitidis; multilocus sequence typing; nucleic acid amplification techniques; penicillin G.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Annual distribution of IMD between 2010 and 2019 in Casablanca, Morocco (n=245).
Fig. 2.
Fig. 2.
Annual distribution of serogroups (2010–2019).
Fig. 3.
Fig. 3.
Reduced susceptibility rate of N. meningitidis isolates to penicillin G during the period from 2010 to 2019 (n=183).
See this image and copyright information in PMC

References

    1. Harrison LH, Pelton SI, Wilder-Smith A, Holst J, Safadi MAP, et al. The global meningococcal initiative: recommendations for reducing the global burden of meningococcal disease. Vaccine. 2011;29:3363–3371. doi: 10.1016/j.vaccine.2011.02.058. - DOI - PubMed
    1. Agnememel A, Hong E, Giorgini D, Nuñez-Samudio V, Deghmane A-E, et al. Neisseria meningitidis serogroup X in sub-Saharan Africa. Emerg Infect Dis. 2016;22:698–702. doi: 10.3201/eid2204.150653. - DOI - PMC - PubMed
    1. Borrow R, Caugant DA, Ceyhan M, Christensen H, Dinleyici EC, et al. Meningococcal disease in the middle East and Africa: findings and updates from the global meningococcal initiative. J Infect. 2017;75:1–11. doi: 10.1016/j.jinf.2017.04.007. - DOI - PubMed
    1. Jones DM, Sutcliffe EM. Meningococci with reduced susceptibility to penicillin. Lancet. 1990;335:863–864. doi: 10.1016/0140-6736(90)90985-E. - DOI - PubMed
    1. Nadel S. Treatment of meningococcal disease. J Adolesc Health. 2016;59:S21–S28. doi: 10.1016/j.jadohealth.2016.04.013. - DOI - PubMed

LinkOut - more resources