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Review
. 2021 Apr 19;60(17):9192-9204.
doi: 10.1002/anie.202006736. Epub 2020 Dec 15.

Asymmetric Catalytic Reactions of Donor-Acceptor Cyclopropanes

Yong Xia  1 , Xiaohua Liu  1 , Xiaoming Feng  1
Affiliations
Review

Asymmetric Catalytic Reactions of Donor-Acceptor Cyclopropanes

Yong Xia et al. Angew Chem Int Ed Engl. .

Abstract

Due to the synergistic "push-pull" effect of vicinal electron-donating and electron-withdrawing groups, donor-acceptor (D-A) cyclopropanes have been recognized as one of the most powerful building blocks to generate polyfunctional reactive intermediates after a strain-driven ring cleavage. Enantioselective reactions of D-A cyclopropanes provide an efficient approach to enantioenriched acyclic and cyclic compounds. A number of chiral Lewis/Brønsted acids, transition metals, and organocatalysts have been designed for such transformations, including ring-openings, annulations, and rearrangements. This minireview highlights the developments and new advances in this field and describes new synthetic opportunities offered by these interesting methodologies.

Keywords: asymmetric synthesis; cycloadditions; donor-acceptor cyclopropanes; rearrangements; ring-opening.

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References

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