Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;9(23):e017580.
doi: 10.1161/JAHA.120.017580. Epub 2020 Oct 14.

Impact of Coronavirus Disease 2019 (COVID-19) on Patients With Congenital Heart Disease Across the Lifespan: The Experience of an Academic Congenital Heart Disease Center in New York City

Matthew J Lewis  1 , Brett R Anderson  2 , Michael Fremed  2 , Melissa Argenio  1 , Usha Krishnan  2 , Rachel Weller  2 , Stéphanie Levasseur  2 , Robert Sommer  1 , Irene D Lytrivi  2 , Emile A Bacha  3 , Julie Vincent  2 , Wendy K Chung  1   2 , Erika B Rosenzweig  2 , Thomas J Starc  2 , Marlon Rosenbaum  1 ; CUIMC Pediatric/Adult Congenital Heart Research Collaborative ‡
Collaborators, Affiliations

Impact of Coronavirus Disease 2019 (COVID-19) on Patients With Congenital Heart Disease Across the Lifespan: The Experience of an Academic Congenital Heart Disease Center in New York City

Matthew J Lewis et al. J Am Heart Assoc. 2020 Dec.

Abstract

Background We sought to assess the impact and predictors of coronavirus disease 2019 (COVID-19) infection and severity in a cohort of patients with congenital heart disease (CHD) at a large CHD center in New York City. Methods and Results We performed a retrospective review of all individuals with CHD followed at Columbia University Irving Medical Center who were diagnosed with COVID-19 between March 1, 2020 and July 1, 2020. The primary end point was moderate/severe response to COVID-19 infection defined as (1) death during COVID-19 infection; or (2) need for hospitalization and/or respiratory support secondary to COVID-19 infection. Among 53 COVID-19-positive patients with CHD, 10 (19%) were <18 years of age (median age 34 years of age). Thirty-one (58%) had complex congenital anatomy including 10 (19%) with a Fontan repair. Eight (15%) had a genetic syndrome, 6 (11%) had pulmonary hypertension, and 9 (17%) were obese. Among adults, 18 (41%) were physiologic class C or D. For the entire cohort, 9 (17%) had a moderate/severe infection, including 3 deaths (6%). After correcting for multiple comparisons, the presence of a genetic syndrome (odds ratio [OR], 35.82; P=0.0002), and in adults, physiological Stage C or D (OR, 19.38; P=0.002) were significantly associated with moderate/severe infection. Conclusions At our CHD center, the number of symptomatic patients with COVID-19 was relatively low. Patients with CHD with a genetic syndrome and adults at advanced physiological stage were at highest risk for moderate/severe infection.

Keywords: COVID‐19; adult congenital heart disease; congenital heart disease; outcomes.

PubMed Disclaimer

Conflict of interest statement

Dr Lewis receives salary support from the National Institutes of Health/NHLBI (K23 HL1143136). Dr Anderson receives salary support from the National Institutes of Health/NHLBI (K23 HL133454). The remaining authors have no disclosures to report.

Figures

Figure 1
Figure 1. Duration of COVID‐19 symptoms by ventricular function.
The median duration of symptom duration for patients with decreased ventricular function (of any ventricle) was 18 days compared with 9 days for patients with normal ventricular function. COVID‐19 indicates coronavirus disease 2019.
See this image and copyright information in PMC

References

    1. Coronavirus Disease 2019 (COVID‐19) . Center for Disease Control. CDC COVID Data Traker. https://covid.cdc.gov/covid‐data‐tracker. Accessed January 7, 2020.
    1. Cheng VC, Lau SK, Woo PC, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev. 2007;20:660–694. - PMC - PubMed
    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, et al. Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed
    1. Mehra MR, Desai SS, Kuy S, Henry TD, Patel AN. Cardiovascular disease, drug therapy, and mortality in Covid‐19. N Engl J Med. 2020;382:e102. - PMC - PubMed
    1. Fried JA, Ramasubbu K, Bhatt R, Topkara VK, Clerkin KJ, Horn E, Rabbani L, Brodie D, Jain SS, Kirtane AJ, et al. The variety of cardiovascular presentations of COVID‐19. Circulation. 2020;141:1930–1936. - PMC - PubMed

MeSH terms