Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

doi:10.1016/j.bbrc.2020.10.102

Review

. 2021 Jan 29:538:88-91.

doi: 10.1016/j.bbrc.2020.10.102. Epub 2020 Nov 6.

Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

Affiliations

¹ Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
² Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland Baltimore, USA.
³ Department of Molecular and Translational Medicine, Section of Microbiology, Universityof Brescia, Brescia, Italy.
⁴ Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
⁵ Dipartimento di Salute Pubblica e Malattie Infettive, Policlinico Umberto I Università'Sapienza', Rome, Italy.
⁶ Anthropology, and Applied Ethics, Campus Bio-Medico University, Rome, Italy.
⁷ Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
⁸ Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy. Electronic address: M.ciccozzi@unicampus.it.

PMID: 33199021
PMCID: PMC7836704
DOI: 10.1016/j.bbrc.2020.10.102

Review

Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

Marta Giovanetti et al. Biochem Biophys Res Commun. 2021.

. 2021 Jan 29:538:88-91.

doi: 10.1016/j.bbrc.2020.10.102. Epub 2020 Nov 6.

Affiliations

¹ Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
² Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland Baltimore, USA.
³ Department of Molecular and Translational Medicine, Section of Microbiology, Universityof Brescia, Brescia, Italy.
⁴ Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
⁵ Dipartimento di Salute Pubblica e Malattie Infettive, Policlinico Umberto I Università'Sapienza', Rome, Italy.
⁶ Anthropology, and Applied Ethics, Campus Bio-Medico University, Rome, Italy.
⁷ Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
⁸ Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy. Electronic address: M.ciccozzi@unicampus.it.

PMID: 33199021
PMCID: PMC7836704
DOI: 10.1016/j.bbrc.2020.10.102

Abstract

An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.

Keywords: Evolution pattern; Mutation; Pandemic; SARS-CoV-2.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

**Fig. 1**
Genome architecture of SARS-CoV-2.

**Fig. 2**
Maximum likelihood phylogeny was estimated with n = 143 complete genomes sequences from the current (2019–2020) SARS-CoV-2 epidemic plus n = 3 closely related bat strains plus n = 2 pangolin strains retrieved from GISAID. Number along branch represent bootstrap score. Scale bar represents expected substitutions per nucleotide site.

See this image and copyright information in PMC

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References

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[1] Wu F., Zhao S., Yu B., Chen Y.M., Wang W., Song Z.G., Hu Y., Tao Z.W., Tian J.H., Pei Y.Y., Yuan M.L., Zhang Y.L., Dai F.H., Liu Y., Wang Q.M., Zheng J.J., Xu L., Holmes E.C., Zhang Y.Z. A new coronavirus associated with human respiratory disease in China. Nature. 2020;10(10):25–38. - PMC - PubMed

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[4] Chan J.F., Kok K.H., Zhu Z., Chu H., To K.K., Yuan S., Yuen K.Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microb. Infect. 2020;28(2):21–236. - PMC - PubMed

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[8] Organization WHO . 2020. Coronavirus Disease (COVID-19) Report.

[9] Khailany R.A., Safdar M., Ozaslan M. Genomic characterization of a novel SARS- CoV-2. Gene Reports. 2020;16(19):100–682. - PMC - PubMed

[10] Khailany R.A., Safdar M., Ozaslan M. Genomic characterization of a novel SARS- CoV-2. Gene Reports. 2020;16(19):100–682. - PMC - PubMed

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Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

Affiliations

Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

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Affiliations

Abstract

Conflict of interest statement

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