Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials

doi:10.1111/jan.14630

Meta-Analysis

. 2021 Feb;77(2):635-652.

doi: 10.1111/jan.14630. Epub 2020 Nov 17.

Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials

Wei Yue¹, Xinrui Han¹, Jianghe Luo¹, Zhumei Zeng¹, Ming Yang^{1

2}

Affiliations

PMID: 33200833
DOI: 10.1111/jan.14630

Meta-Analysis

Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials

Wei Yue et al. J Adv Nurs. 2021 Feb.

. 2021 Feb;77(2):635-652.

doi: 10.1111/jan.14630. Epub 2020 Nov 17.

Authors

Wei Yue¹, Xinrui Han¹, Jianghe Luo¹, Zhumei Zeng¹, Ming Yang^{1

2}

Affiliations

¹ School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, China.
² Guangzhou University City, Guangzhou, China.

PMID: 33200833
DOI: 10.1111/jan.14630

Abstract
in English, Chinese

Aim: To systematically examine the effectiveness of music therapy on preterm infants in neonatal intensive care unit.

Background: In recent years, the application of music therapy for preterm infants in neonatal intensive care unit has attracted more and more attention because of its clinical effects. However, there still exist disputes among different studies.

Design: A systematic review and meta-analysis.

Data sources: Eleven databases were searched over the period from 1910 -4 November 2019.

Review methods: Papers were selected for analysis in accordance with the PRISMA guidelines. The meta-analysis was carried out by using Review Manager 5.3 software.

Results: A total of 13 trials involving 1,093 participants were included. Meta-analysis showed music therapy had a significant influence on preterm infant's heart rate, respiratory rate, oral feeding volume, stress level, and maternal anxiety with moderate-to-high heterogeneity among studies. Also, music therapy had no influences on oxygen saturation and behavioural state.

Conclusions: Music therapy can not only effectively improve preterm infant's heart rate, stable respiratory rate, and attenuate stress level but also exert positive impact on oral feeding volume. In addition, music therapy also plays a role in reducing maternal anxiety. However, due to the heterogeneity across studies in some outcomes, further studies with larger sample size and more stringent design should be conducted before recommendation.

Impact: Music therapy can significantly improve preterm infant's heart rate, respiratory rate, and stress level, as well as increase oral feeding volume. These results may exert a positive impact on well-being and quality of life in preterm infants in the neonatal intensive care unit. Hospitals can apply music therapy which has been considered a non-pharmacological and no-invasive treatment to preterm infants in the neonatal intensive care unit.

目的: 系统性地检查音乐疗法对新生儿重症监护室内的早产儿的效果。背景: 近年来,由于临床效果显著,音乐疗法对于新生儿重症监护室内早产儿的应用受到越来越多的关注。然而,不同的研究之间仍存在争议。设计: 采用系统评估和荟萃分析。数据来源: 对11个数据库自1910年至2019年11月4日期间的数据进行检索。评估方法: 根据RPISMA指南选择用于分析的论文。通过Review Manager 5.3软件进行荟萃分析。结果: 共涉及13次试验以及1,093位参与者。荟萃分析显示,音乐疗法对早产儿心率、呼吸频率、经口喂养量、压力水平以及母亲焦虑度有显著影响,各研究间存在中等到高度异质性。但音乐疗法对氧饱和度和行为状态并无影响。结论: 音乐疗法不仅可以有效改善早产儿心率、稳定呼吸速率、改善压力水平,还对经口喂养量产生积极的影响。此外,音乐疗法在减少母亲的焦虑度方面也起着重要的作用。但是,因部分研究结果的异质性,在推荐使用该疗法前还应进一步研究更多的样本和进行更严格的设计。影响: 音乐疗法可以显著改善早产儿心率、呼吸速率、压力水平,并增加经口喂养量。这些结果可能对新生儿重症监护室内早产儿的健康和生活质量带来积极的影响。医院可采用被认为是非药物和无创伤治疗的音乐疗法,为新生儿重症监护室内的早产儿提供治疗。.

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References

1. Aalbers, S., Fusar-Poli, L., Freeman, R. E., Spreen, M., Ket, J. C. F., Vink, A. C., Maratos, A., Crawford, M., Chen, X.-J., & Gold, C. (2017). Music therapy for depression. Cochrane Database of Systematic Reviews, 2017, CD004517.
1. Alipour, Z., Eskandari, N., Ahmari, T. H., Eshagh, H. S. K., & Sangi, S. (2013). Effects of music on physiological and behavioral responses of premature infants: A randomized controlled trial. Complement Therapies in Clinical Practice, 19(3), 128-132. https://doi.org/10.1016/j.ctcp.2013.02.007
1. Amini, E., Rafiei, P., Zarei, K., Gohari, M., & Hamidi, M. (2013). Effect of lullaby and classical music on physiologic stability of hospitalized preterm infants: A randomized trial. Journal of Neonatal-Perinatal Medicine, 6(4), 295-301. https://doi.org/10.3233/NPM-1371313
1. Anderson, D. E., & Patel, A. D. (2018). Infants born preterm, stress and neurodevelopment in the neonatal intensive care unit: Might music have an impact? Developmental Medicine & Child Neurology, 60(3), 256-266. https://doi.org/10.1111/dmcn.13663
1. Arnon, S., Diamant, C., Bauer, S., Regev, R., Sirota, G., & Litmanovitz, I. (2014). Maternal singing during kangaroo care led to autonomic stability in preterm infants and reduced maternal anxiety. Acta Paediatrica, 103(10), 1039-1044. https://doi.org/10.1111/apa.12744

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[1] Aalbers, S., Fusar-Poli, L., Freeman, R. E., Spreen, M., Ket, J. C. F., Vink, A. C., Maratos, A., Crawford, M., Chen, X.-J., & Gold, C. (2017). Music therapy for depression. Cochrane Database of Systematic Reviews, 2017, CD004517.

[2] Aalbers, S., Fusar-Poli, L., Freeman, R. E., Spreen, M., Ket, J. C. F., Vink, A. C., Maratos, A., Crawford, M., Chen, X.-J., & Gold, C. (2017). Music therapy for depression. Cochrane Database of Systematic Reviews, 2017, CD004517.

[3] Alipour, Z., Eskandari, N., Ahmari, T. H., Eshagh, H. S. K., & Sangi, S. (2013). Effects of music on physiological and behavioral responses of premature infants: A randomized controlled trial. Complement Therapies in Clinical Practice, 19(3), 128-132. https://doi.org/10.1016/j.ctcp.2013.02.007

[4] Alipour, Z., Eskandari, N., Ahmari, T. H., Eshagh, H. S. K., & Sangi, S. (2013). Effects of music on physiological and behavioral responses of premature infants: A randomized controlled trial. Complement Therapies in Clinical Practice, 19(3), 128-132. https://doi.org/10.1016/j.ctcp.2013.02.007

[5] Amini, E., Rafiei, P., Zarei, K., Gohari, M., & Hamidi, M. (2013). Effect of lullaby and classical music on physiologic stability of hospitalized preterm infants: A randomized trial. Journal of Neonatal-Perinatal Medicine, 6(4), 295-301. https://doi.org/10.3233/NPM-1371313

[6] Amini, E., Rafiei, P., Zarei, K., Gohari, M., & Hamidi, M. (2013). Effect of lullaby and classical music on physiologic stability of hospitalized preterm infants: A randomized trial. Journal of Neonatal-Perinatal Medicine, 6(4), 295-301. https://doi.org/10.3233/NPM-1371313

[7] Anderson, D. E., & Patel, A. D. (2018). Infants born preterm, stress and neurodevelopment in the neonatal intensive care unit: Might music have an impact? Developmental Medicine & Child Neurology, 60(3), 256-266. https://doi.org/10.1111/dmcn.13663

[8] Anderson, D. E., & Patel, A. D. (2018). Infants born preterm, stress and neurodevelopment in the neonatal intensive care unit: Might music have an impact? Developmental Medicine & Child Neurology, 60(3), 256-266. https://doi.org/10.1111/dmcn.13663

[9] Arnon, S., Diamant, C., Bauer, S., Regev, R., Sirota, G., & Litmanovitz, I. (2014). Maternal singing during kangaroo care led to autonomic stability in preterm infants and reduced maternal anxiety. Acta Paediatrica, 103(10), 1039-1044. https://doi.org/10.1111/apa.12744

[10] Arnon, S., Diamant, C., Bauer, S., Regev, R., Sirota, G., & Litmanovitz, I. (2014). Maternal singing during kangaroo care led to autonomic stability in preterm infants and reduced maternal anxiety. Acta Paediatrica, 103(10), 1039-1044. https://doi.org/10.1111/apa.12744

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Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials

Affiliations

Effect of music therapy on preterm infants in neonatal intensive care unit: Systematic review and meta-analysis of randomized controlled trials

Authors

Affiliations

Abstract
in English, Chinese

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract in English, Chinese

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract
in English, Chinese