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Multicenter Study
. 2021 Mar;9(2):567-578.
doi: 10.1007/s43390-020-00233-y. Epub 2020 Nov 17.

Risk factors for gastrointestinal complications after spinal fusion in children with cerebral palsy

Bram P Verhofste  1 , Jay G Berry  1 , Patricia E Miller  1 , Charis N Crofton  1 , Brigid M Garrity  1 , Nicholas D Fletcher  2 , Michelle C Marks  3 , Suken A Shah  4 , Peter O Newton  5 , Amer F Samdani  6 , Mark F Abel  7 , Paul D Sponseller  8 ; Harms Study Group; Michael P Glotzbecker  9
Affiliations
Multicenter Study

Risk factors for gastrointestinal complications after spinal fusion in children with cerebral palsy

Bram P Verhofste et al. Spine Deform. 2021 Mar.

Abstract

Design: Prospective cerebral palsy (CP) registry review.

Objectives: (1) Evaluate the incidence/risk factors of gastrointestinal (GI) complications in CP patients after spinal fusion (SF); and (2) investigate the validity of the modified Clavien-Dindo-Sink classification.

Background: Perioperative GI complications result in increased length of stay (LOS) and patient morbidity/mortality. However, none have analyzed the outcomes of GI complications using an objective classification system.

Methods: A prospective/multicenter CP database identified 425 children (mean, 14.4 ± 2.9 years; range, 7.9-21 years) who underwent SF. GI complications were categorized using the modified Clavien-Dindo-Sink classification. Grades I-II were minor complications and grades III-V major. Patients with and without GI complications were compared.

Results: 87 GI complications developed in 69 patients (16.2%): 39 minor (57%) and 30 major (43%). Most common were pancreatitis (n = 45) and ileus (n = 22). Patients with preoperative G-tubes had 2.2 × odds of developing a GI complication compared to oral-only feeders (OR 2.2; 95% CI 0.98-4.78; p = 0.006). Similarly, combined G-tube/oral feeders had 6.7 × odds compared to oral-only (OR 6.7; 95% CI 3.10-14.66; p < 0.001). The likelihood of developing a GI complication was 3.4 × with normalized estimated blood loss (nEBL) ≥ 3 ml/kg/level fused (OR 3.41; 95% CI 1.95-5.95; p < 0.001). Patients with GI complications had more fundoplications (29% vs. 17%; p = 0.03) and longer G-tube fasting periods (3 days vs. 2 days; p < 0.001), oral fasting periods (5 days vs. 2 days; p < 0.001), ICU admissions (6 days vs. 3 days; p = 0.002), and LOS (15 days vs. 8 days; p < 0.001). LOS correlated with the Clavien-Dino-Sink classification.

Conclusion: Gastrointestinal complications such as pancreatitis and ileus are not uncommon after SF in children with CP. This is the first study to investigate the validity of the modified Clavien-Dindo-Sink classification in GI complications after SF. Our results suggest a correlation between complication severity grade and LOS. The complexity of perioperative enteral nutritional supplementation requires prospective studies dedicated to enteral feeding protocols.

Level of evidence: Therapeutic-level III.

Keywords: Cerebral palsy; Complications; Gastrointestinal complications; Pediatric; Scoliosis; Spinal fusion.

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References

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