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. 2020 Nov:6:1766-1771.
doi: 10.1200/GO.20.00426.

Trends in Melanoma Mortality in Brazil: A Registry-Based Study

Guilherme Nader Marta  1   2 , Rodrigo Ramella Munhoz  1   3 , Monica La Porte Teixeira  4 , Bernadette Cunha Waldvogel  4 , Veridiana Pires de Camargo  1   2 , Olavo Feher  1   3 , Jose Antonio Sanches  5
Affiliations

Trends in Melanoma Mortality in Brazil: A Registry-Based Study

Guilherme Nader Marta et al. JCO Glob Oncol. 2020 Nov.

Abstract

Purpose: A substantial increase in melanoma incidence has been consistently observed worldwide over the past decades. However, melanoma mortality rates have remained stable or declined over the past years in most regions. Given the paucity of melanoma mortality data for different Brazilian regions, we sought to describe melanoma mortality trends in southeastern Brazil and their relationship with demographic variables.

Materials and methods: A cross-sectional registry-based analysis was conducted to describe melanoma mortality trends in the state of São Paulo, Brazil, from 1996 to 2016. Demographic information from melanoma-related death records, including sex and age, was collected from the Fundação Sistema Estadual de Análise de Dados database. The annual percentage change (APC) was calculated to identify mortality trends over the period.

Results: An increasing melanoma mortality trend was detected among males, regardless of age (APC, 1.72%; P < .001), and was more pronounced for men ≥ 60 years old (APC, 2.63%; P < .001). Melanoma mortality rates have also increased for patients ≥ 60 years old, regardless of sex (APC, 1.11%; P < .001). A non-statistically significant increase in the overall melanoma mortality rate was observed over the 20-year period analyzed (APC, 0.36%; P = .4).

Conclusion: Our data suggest a stable melanoma mortality over the past two decades for the overall population studied; however, a significant increase in melanoma mortality rates has been demonstrated among males and in the population ≥ 60 years old, emphasizing the need to implement prevention strategies and expand access to effective therapies for this population.

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Conflict of interest statement

Guilherme Nader Marta

Travel, Accommodations, Expenses: Bayer Schering Pharma, Roche

Rodrigo Ramella Munhoz

Honoraria: Bristol Myers Squibb, MSD, Roche, Novartis, Sanofi, Merck Serono

Consulting or Advisory Role: Roche, Merck Serono, Sanofi, Bristol Myers Squibb

Speakers' Bureau: Bristol Myers Squibb, MSD, Novartis, Roche

Research Funding: Eli Lilly, Roche, Bristol Myers Squibb, Novartis, MSD

Travel, Accommodations, Expenses: Bristol Myers Squibb, MSD, Roche, Sanofi

Olavo Feher

Speakers' Bureau: Foundation Medicine

Research Funding: Foundation Medicine

Travel, Accommodations, Expenses: Roche

Uncompensated Relationships: Bayer

Jose Antonio Sanches Jr

Speakers' Bureau: Takeda

No other potential conflicts of interest were reported.

Figures

FIG 1
FIG 1
Standardized melanoma mortality rates (per 100,000) by sex in the state of São Paulo (Brazil) from 1996 to 2016.
FIG 2
FIG 2
Melanoma mortality trends (per 100,000) by age groups in the state of São Paulo (Brazil) from 1996 to 2016.
See this image and copyright information in PMC

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