Membrane Protein Biogenesis: PAT Complex Pats Membrane Proteins into Shape
- PMID: 33202243
- DOI: 10.1016/j.cub.2020.09.072
Membrane Protein Biogenesis: PAT Complex Pats Membrane Proteins into Shape
Abstract
Membrane proteins with multiple transmembrane domains play essential roles in the cell, but little is known about the machinery involved in the assembly of these domains into functional proteins. Two recent studies report the discovery of novel membrane protein chaperone complexes for the biogenesis of multi-pass membrane proteins.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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An intramembrane chaperone complex facilitates membrane protein biogenesis.Nature. 2020 Aug;584(7822):630-634. doi: 10.1038/s41586-020-2624-y. Epub 2020 Aug 19. Nature. 2020. PMID: 32814900 Free PMC article.
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An ER translocon for multi-pass membrane protein biogenesis.Elife. 2020 Aug 21;9:e56889. doi: 10.7554/eLife.56889. Elife. 2020. PMID: 32820719 Free PMC article.
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