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. 2020 Nov 14;21(22):8582.
doi: 10.3390/ijms21228582.

The Role of Chemokine Receptor CXCR3 and Its Ligands in Renal Cell Carcinoma

Monika Gudowska-Sawczuk  1 , Jacek Kudelski  2 , Barbara Mroczko  1   3
Affiliations

The Role of Chemokine Receptor CXCR3 and Its Ligands in Renal Cell Carcinoma

Monika Gudowska-Sawczuk et al. Int J Mol Sci. .

Abstract

The major invasive subtype of kidney cancer is renal cell carcinoma (RCC). The essential components of cancer development are chronic inflammation and neoangiogenesis. It has been suggested that the chemokine ligand 9, -10, -11 (CXCL9-11) and chemokine receptor 3 (CXCR3) chemokines receptor expressed on monocytes, T and NK cells may be involved in the inhibition of angiogenesis. However, to date, little is known about the potential clinical significance of these chemokines and their receptor in renal cell carcinoma. Therefore, in this review, we described the role of CXCR3 and its ligands in pathogenesis of RCC. We performed an extensive search of the current literature in our investigation, using the MEDLINE/PubMed database. The changes of chemokines and their specific receptor in renal cell carcinoma were observed. Published studies revealed an increased expression of CXCR3 and elevated concentration of its ligands in RCC. The association between treatment of RCC and CXCL9-11/CXCR3 concentration and expression was also observed. Moreover, CXCR3 and its ligands levels were related to patient's prognosis, risk of metastasis and tumor growth. This review describes the potential role of CXCR3 and its ligands in pathogenesis of RCC, as well as their potential immune-therapeutic significance. However, future studies should aim to confirm the clinical and prognostic role of CXCL9-11/CXCR3 in renal cell carcinoma.

Keywords: CXCR3; chemokines; metastasis; renal cell carcinoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic illustration of articles included in the review manuscript [14].
See this image and copyright information in PMC

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