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Randomized Controlled Trial
. 2020 Nov 13;12(11):3495.
doi: 10.3390/nu12113495.

Isoflavone Supplementation Does Not Potentiate the Effect of Combined Exercise Training on Resting and Ambulatory Blood Pressure in Non-Obese Postmenopausal Women: A Randomized Double-Blind Controlled Trial-A Pilot Study

Juliene G C Dechichi  1 , Igor M Mariano  1 , Jéssica S Giolo  1 , Jaqueline P Batista  1 , Ana Luiza Amaral  1 , Paula A B Ribeiro  2 , Erick P de Oliveira  3 , Guilherme M Puga  1
Affiliations
Randomized Controlled Trial

Isoflavone Supplementation Does Not Potentiate the Effect of Combined Exercise Training on Resting and Ambulatory Blood Pressure in Non-Obese Postmenopausal Women: A Randomized Double-Blind Controlled Trial-A Pilot Study

Juliene G C Dechichi et al. Nutrients. .

Abstract

Physical exercise and isoflavone supplementation are potential strategies to prevent and treat cardiovascular diseases in postmenopausal women. The aim of this study was to investigate whether there are additive effects of isoflavone supplementation when associated with combined aerobic and resistance exercise on resting and ambulatory blood pressure monitoring (ABPM) and in blood pressure variability (BPV). Thirty-one non-obese postmenopausal women were randomly allocated into two groups: placebo and exercise (Placebo n = 19); and isoflavone supplementation (100 mg/day) and exercise (isoflavone n = 19). ABPM and BPV were evaluated before and after 10 weeks of moderate combined (aerobic and resistance) exercise training. Generalized Estimating Equation (GEE) with Bonferroni correction and intention-to-treat analysis was used to compare the effects of interventions on resting BP, ABPM and BPV. Combined exercise training decreased resting systolic (SBP) and diastolic blood pressure (DBP) and reduced 24 h and awake ambulatory SBP, DBP and mean blood pressure over time, with no additional effects of isoflavone supplementation. No changes were observed in sleep period, or in BPV indexes (Standard Deviation of 24 h (SD), daytime and nighttime interval (SDdn) and average real variability (ARV) in both groups. We conclude that isoflavone supplementation does not potentiate the effects of combined training on resting and ambulatorial systolic and diastolic blood pressure in non-obese postmenopausal women.

Keywords: aerobic exercise; ambulatory blood pressure monitoring; blood pressure variability; menopause; soy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study participants.
Figure 2
Figure 2
Intention-to-treat analysis of resting and ambulatory blood bressure monitoring AMBP results during 24 h, night-time and daytime periods (mean ± SD). PLA: placebo and exercise group; ISO: isoflavone and exercise group; SBP: systolic blood pressure; DBP: diastolic blood pressure; MBP: mean blood pressure; Pre: Measures pre interventions; Post: Measures post interventions.
Figure 3
Figure 3
Values of serum NO2− variation in both placebo (PLA) and isoflavone (ISO) groups. EXE: exercise; Δ: final minus baseline values. ANOVA two way was used to compare groups and time. Student t-test was used to compare delta values.
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