Comparison between blue-on-yellow and white-on-white perimetry in patients with branch retinal vein occlusion

Abstract

This study aimed to compare blue-on-yellow (B/Y) perimetry with white-on-white (W/W) perimetry in eyes with branch retinal vein occlusion (BRVO). The following measurements were performed in 29 eyes of 29 patients with resolved BRVO: W/W and B/Y perimetries using 10-2 test grid, retinal volume (RV) using optical coherence tomography (OCT), and vessel densities (VD) of the superficial capillary layer (VDs) and deep capillary layer (VDd) using OCT angiography (OCTA). First, the difference in the retinal sensitivity (RS) between BRVO-affected and unaffected areas was compared between RS_B/Y and RS_W/W in the parafoveal and extrafoveal areas. Moreover, the structure-function relationship between vessel density and RS was compared between B/Y and W/W perimetries (RS_B/Y and RS_W/W, respectively). The difference in RS between BRVO-affected and unaffected areas was significantly larger with RS_B/Y than with RS_W/W in both the parafoveal and extrafoveal areas. In the parafoveal area, VDs, VDd, and RV were significantly correlated with both RS_W/W and RS_B/Y. In contrast, in the extrafoveal area, only VDd was included in the optimal models. Our findings suggest that RS_B/Y more strongly reflects the anatomical structure and BRVO-affected area.

Figure 1

Comparison of the difference in RS between the BRVO-affected and unaffected areas using both perimetries. (a) Comparison in the parafovea, (b) comparison in the extrafovea. The difference with B/Y perimetry was significantly larger than that with W/W perimetry in both regions (the paired Student’s t test). The images were generated using R software version 3.5.2, following the guideline (https://cran.r-project.org/doc/FAQ/R-FAQ.html#Citing-R). RS retinal sensitivity, BRVO branch retinal vein occlusion, B/Y blue on yellow, W/W white on white.

Figure 2

Sectorization of the macula. The built-in OCT software automatically analyzed the mean retinal thickness and volume in each of the nine macular regions in a 6-mm-diameter circle that was centered on the fovea, as defined in ETDRS. The diameter of the central circle was 1 mm, that of the inner ring was 3 mm, and that of the outer ring was 6 mm. The center circle was defined as the center, the inner ring as the parafovea, and the outer ring as the extrafovea. VF visual field, ETDRS Early Treatment of Diabetic Retinopathy Study.

Figure 3

Mapping of VF. All 68 points were assigned to each of the nine regions after ETDRS. The mean retinal sensitivity was calculated in each sector. OCT optical coherence tomography.

Figure 4

Comparison of the RS between BRVO-affected and unaffected areas. In the parafovea, the difference between areas 2 and 4 was calculated using both B/Y and W/W perimetries. In the extrafovea, the difference between areas 6 and 8 was calculated. RS retinal sensitivity, B/Y blue on yellow, W/W white on white, BRVO branch retinal vein occlusion.