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Review
. 2021 Jan;18(1):3-4.
doi: 10.1038/s41575-020-00389-y.

COVID-19 and acute pancreatitis: examining the causality

Enrique de-Madaria  1   2 , Gabriele Capurso  3
Affiliations
Review

COVID-19 and acute pancreatitis: examining the causality

Enrique de-Madaria et al. Nat Rev Gastroenterol Hepatol. 2021 Jan.

Abstract

Case reports and retrospective cohort studies have reported an association between acute pancreatitis and COVID-19. As SARS-CoV-2 (the causative agent of COVID-19) receptors are expressed in the pancreas and endothelial damage can occur, this association is plausible. However, this hypothesis has many biases and needs further investigation.

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Conflict of interest statement

The authors declare no competing interests.

Comment in

  • Covid-19 and risk of acute pancreatitis: What beyond.
    Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Bahaa MM, Batiha GE. Al-Kuraishy HM, et al. J Cell Mol Med. 2024 Jan;28(1):e18082. doi: 10.1111/jcmm.18082. Epub 2023 Dec 15. J Cell Mol Med. 2024. PMID: 38102841 Free PMC article. No abstract available.

References

    1. Boxhoorn L, et al. Acute pancreatitis. Lancet. 2020;396:726–734. doi: 10.1016/S0140-6736(20)31310-6. - DOI - PubMed
    1. Lucas RM, McMichael AJ. Association or causation: evaluating links between “environment and disease”. Bull World Health Organ. 2005;83:792–795. - PMC - PubMed
    1. Xiao F, et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020;158:1831–1833. doi: 10.1053/j.gastro.2020.02.055. - DOI - PMC - PubMed
    1. Liu F, et al. ACE2 Expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection. Clin. Gastroenterol. Hepatol. 2020;18:2128–2130. doi: 10.1016/j.cgh.2020.04.040. - DOI - PMC - PubMed
    1. Schepis T, et al. SARS-CoV2 RNA detection in a pancreatic pseudocyst sample. Pancreatology. 2020;20:1011–1012. doi: 10.1016/j.pan.2020.05.016. - DOI - PMC - PubMed