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Review
. 2020 Nov 11:13:4077-4089.
doi: 10.2147/IDR.S240162. eCollection 2020.

Management of Acute Bacterial Meningitis in Children

Zain Alamarat  1 , Rodrigo Hasbun  2
Affiliations
Review

Management of Acute Bacterial Meningitis in Children

Zain Alamarat et al. Infect Drug Resist. .

Abstract

Acute community-acquired bacterial meningitis (ABM) in children continues to have high rates of neurological morbidity and mortality despite the overall declining rates of infection attributed to the use of vaccines and intrapartum Group B Streptococcus prophylaxis. Prompt diagnosis and early antibiotic therapy are crucial and should not be delayed to obtain cranial imaging. Differentiating bacterial from viral meningitis continues to be a clinical dilemma especially in patients with previous antibiotic exposure. Clinical models and inflammatory biomarkers can aid clinicians in their diagnostic approach. Multiplex polymerase chain reaction and metagenomic next-generation sequencing are promising tools that can help in early and accurate diagnosis. This review will present the epidemiology of ABM in children, indications of cranial imaging, role of different models and serum biomarkers in diagnosing ABM, and management including the use of adjunctive therapies and methods of prevention.

Keywords: CNS infection; bacterial meningitis; children; management; meningitis.

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Conflict of interest statement

RH has received research support, grants, and personal fees from Biofire®, outside the submitted work, and reports no other potential conflicts of interest for this work. ZA has no conflicts of interest for this work.

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