Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 3:2020:9461901.
doi: 10.1155/2020/9461901. eCollection 2020.

Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis

Mizan Kindu  1 , Lemma Derseh  2 , Baye Gelaw  1 , Feleke Moges  1
Affiliations
Review

Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis

Mizan Kindu et al. Int J Microbiol. .

Abstract

Background: Studies have reported that the existence of CP bacteria in Africa, but, in general, comprehensive data about the molecular epidemiology of CP organisms are limited. Therefore, this systematic review and meta-analysis expound the pooled prevalence of CP P. aeruginosa and CP A. baumannii clinical isolates in Africa. It also identified the diversity of carbapenemases or their encoding genes among the isolates in Africa. Lastly, the review observed the trends of these CP isolates in Africa.

Methods: A comprehensive search was performed between July 2019 and October 2019 in the following databases: PubMed, Google Scholar, and African Journal online. The included articles were published only in English. The screening was done by two authors independently. The data extracted on Excel spreadsheet were transferred to STATA 11 software for analysis.

Results: From a total of 1,454 articles searched, 42 articles were eligible. Most of the studies were conducted in the North Africa region. But there was no report from Central Africa. The pooled prevalence of CP P. aeruginosa and CP A. baumannii among the clinical specimens in Africa was 21.36% and 56.97%, respectively. OXA-23 and VIM were the most prevailing carbapenemase among P. aeruginosa and A. baumannii, respectively. The cumulative meta-analysis revealed a relative increment of the prevalence of CP P. aeruginosa over time in Africa but it showed a higher prevalence of CP A. baumannii isolates across years.

Conclusion: The review revealed a high pooled prevalence of CP A. baumannii clinical isolates in Africa which needs urgent action. Moreover, the emergence of concomitant carbapenemases, especially OXA-23 + NDM among CP A. baumannii, was also an alarming problem.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart shows the study selection process.
Figure 2
Figure 2
Geographical distribution CPPA isolates in Africa from 2007 to 2018 G.C.
Figure 3
Figure 3
Forest plot for the pooled prevalence of CPPA isolates in Africa from 2007 to 2018 G.C.
Figure 4
Figure 4
Subgroup analysis for the pooled prevalence of CPPA isolates in Africa by country from 2007 to 2018 G.C.
Figure 5
Figure 5
Sensitivity analysis for the pooled prevalence of CPPA in Africa from 2007 to 2018 G.C.
Figure 6
Figure 6
Funnel plot for publication bias of pooled prevalence of CPPA in Africa from 2007 to 2018 G.C.
Figure 7
Figure 7
Cumulative meta-analysis of CPPA between 2014 and 2019 G.C. in Africa.
Figure 8
Figure 8
Geographical distribution of CPAB isolates in Africa from 2007 to 2017 G.C.
Figure 9
Figure 9
Forest plot for the pooled prevalence of CPAB isolates in Africa from 2007 to 2017 G.C.
Figure 10
Figure 10
Subgroup analysis for the pooled prevalence of CPAB in Africa by country from 2007 to 2017 G.C.
Figure 11
Figure 11
Sensitivity analysis for the pooled prevalence of CPAB in Africa from 2007 to 2017 G.C.
Figure 12
Figure 12
Funnel plot for publication bias of pooled prevalence of CPAB in Africa from 2007 to 2017 G.C.
Figure 13
Figure 13
Cumulative meta-analysis of CPAB between 2015 and 2019 in Africa.
See this image and copyright information in PMC

References

    1. Tacconelli E., Carrara E., Savoldi A., Harbarth S., Mendelson M., Monnet D. L. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet Infectious Diseases. 2018;18(3):318–327. doi: 10.1016/s1473-3099(17)30753-3. - DOI - PubMed
    1. World Health Organization (WHO) Antimicrobial Resistance: Global Report on Surveillance. Geneva, Switzerland: World Health Organization; 2014.
    1. MacVane S. H. Antimicrobial resistance in the intensive care unit. Journal of Intensive Care Medicine. 2017;32(1):25–37. doi: 10.1177/0885066615619895. - DOI - PubMed
    1. Codjoe F., Donkor E. Carbapenem resistance: a review. Medical Sciences. 2017;6(1) doi: 10.3390/medsci6010001. - DOI - PMC - PubMed
    1. Sahuquillo-Arce J. M., Hernández-Cabezas A., Yarad-Auad F., et al. Carbapenemases: a worldwide threat to antimicrobial therapy. World Journal of Pharmacology. 2015;4(1):75–95. doi: 10.5497/wjp.v4.i1.75. - DOI

LinkOut - more resources