Determination of the anticonvulsant drug--dipropyl acetate (Epilim) in human plasma by gas chromatography
- PMID: 332044
- DOI: 10.1177/000456327701400164
Determination of the anticonvulsant drug--dipropyl acetate (Epilim) in human plasma by gas chromatography
Abstract
A relatively simple gas chromatographic procedure is proposed for the analysis of the drug dipropylacetic acid in plasma. The compound is chromatographed, as the free acid after ether extraction. Prior to concentration of the solvent the acid is converted to its potassium salt, then regenerated to the free acid immediately before analysis.
Similar articles
-
Rapid determination of valproate sodium in serum by gas-liquid chromatography.Epilepsia. 1977 Jun;18(2):225-7. doi: 10.1111/j.1528-1157.1977.tb04469.x. Epilepsia. 1977. PMID: 326546
-
Gas chromatographic determination of valproic acid in human plasma.J Chromatogr. 1977 Feb 1;132(1):145-7. doi: 10.1016/s0021-9673(00)93784-1. J Chromatogr. 1977. PMID: 319102 No abstract available.
-
Gas chromatographic measurement of plasma levels of sodium valproate: tentative therapeutic range of a new anticonvulsant in the treatment of refractory epileptics.Clin Exp Pharmacol Physiol. 1978 Jan-Feb;5(1):67-73. doi: 10.1111/j.1440-1681.1978.tb00653.x. Clin Exp Pharmacol Physiol. 1978. PMID: 346272
-
The estimation of plasma valproate by gas-liquid chromatography.Clin Chim Acta. 1977 Jun 15;77(3):343-7. doi: 10.1016/0009-8981(77)90239-x. Clin Chim Acta. 1977. PMID: 326442
-
A rapid and sensitive gas-liquid chromatographic procedure for the micro determination of sodium valproate (sodium di-N-propylacetate) in plasma or serum.Clin Chim Acta. 1977 Dec 1;81(2):203-8. doi: 10.1016/0009-8981(77)90012-2. Clin Chim Acta. 1977. PMID: 338203
Cited by
-
Lack of hepatic enzyme inducing effect of sodium valproate.Br J Clin Pharmacol. 1979 Aug;8(2):189-90. doi: 10.1111/j.1365-2125.1979.tb05821.x. Br J Clin Pharmacol. 1979. PMID: 385027 Free PMC article. No abstract available.
-
Valproic acid and diazepam interaction in vivo.Br J Clin Pharmacol. 1982 Apr;13(4):553-60. doi: 10.1111/j.1365-2125.1982.tb01421.x. Br J Clin Pharmacol. 1982. PMID: 6802161 Free PMC article.
-
Disposition of sodium valproate in epileptic patients.Br J Clin Pharmacol. 1978 Jun;5(6):495-9. doi: 10.1111/j.1365-2125.1978.tb01663.x. Br J Clin Pharmacol. 1978. PMID: 350251 Free PMC article. Clinical Trial.
-
Decreased plasma protein binding of phenytoin in patients on valproic acid.Br J Clin Pharmacol. 1979 Dec;8(6):547-52. doi: 10.1111/j.1365-2125.1979.tb01042.x. Br J Clin Pharmacol. 1979. PMID: 391256 Free PMC article.
-
Modification of phenytoin clearance by valproic acid in normal subjects.Br J Clin Pharmacol. 1979 Dec;8(6):553-6. doi: 10.1111/j.1365-2125.1979.tb01043.x. Br J Clin Pharmacol. 1979. PMID: 391257 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources