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. 2020 Oct 21:26:100333.
doi: 10.1016/j.jbo.2020.100333. eCollection 2021 Feb.

Desmoplastic fibroma of the jaw bones: A series of twenty-two cases

Devrim Kahraman  1 , Berkem Karakoyunlu  2 , Ulker Karagece  3 , Umit Ertas  4 , Omer Gunhan  1
Affiliations

Desmoplastic fibroma of the jaw bones: A series of twenty-two cases

Devrim Kahraman et al. J Bone Oncol. .

Abstract

Desmoplastic fibroma (DF) is an intraosseous counterpart of desmoid-type soft tissue fibromatosis. It is most frequently seen in the jawbones. The clinical and radiological features of the present cases were nonspecific. The accumulation of beta-catenin in the nuclei of neoplastic cells which is a diagnostic feature of desmoid-type soft tissue fibromatosis could not be detectED in the present DF series. The aim of this study is to report a series of 22 cases of DF involving either mandible or maxilla. A retrospective evaluation of desmoplastic fibroma and beta-catenin, smooth muscle actin, nestin, cyclin D1 immunostaining's patterns. Most of the DF cases expressed only cytoplasmic beta-catenin immunostainings. We suggest that nuclear beta-catenin staining may not be used as a corroborating the diagnosis of DF. Immunohistochemical staining difference of jaw bone desmoplastic fibromas from other soft tissue and bone lesions may be related to the origination of jaw bone from The neural crest. Strong nestin and cyclin D1 positivity in our series supported this. A combined clinical, radiological, and histopathological analysis of the DF cases is essential in the diagnosis and management.

Keywords: Beta-catenin; Desmoplastic fibroma; Fibromatosis; Jaw bones; Nestin; Neural crest.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Large multilocular radiolucency and expansion in the left angulus mandible caused by desmoplastic fibroma (case 9).
Fig. 2
Fig. 2
The pre-operative panoramic radiograph of a desmoplastic fibroma of the mandible in a child (case 21) shows a radiolucent area in the anterior region causing teeth displacement.
Fig. 3
Fig. 3
Desmoplastic fibroma extending through cortical bone trabeculae (HEX100).
Fig. 4
Fig. 4
Histologic appearance showing fascicles of spindle fibroblastic proliferation of desmoplastic fibroma (a). Some cases contained plump fibroblasts and more collagenized matrix (b) and others were more cellular (c). (HEX200).
Fig. 5
Fig. 5
The neoplastic spindle cells of desmoplastic fibromas showed cytoplasmic immunoreactivity for beta-catenin and nestin (a, b) without any nuclear staining. Some cases showed nuclear cyclin D1 reactivity (c), Streptavidin-peroxidase techniqueX400).
Fig. 6
Fig. 6
Control immunostainings: Desmoid-type soft tissue fibromatosis used as control tissue and showed strong nuclear beta-catenin immunopositivity (a). There was strong cytoplasmic positivity for smooth muscle actin in a case of desmoplastic fibroma. Vessels within the lesion were positive control (b). Control positive nestin immunostaining of kidney section seen predominantly in glomeruli(c). Tonsil tissue served control tissue of cyclin D1 immunostaining. Suprabasal squamous epithelial cells, scattered lymphocytes, and endothelial cells showed strong nuclear immunostaining (d). (Streptavidin-peroxidase techniqueX400).
See this image and copyright information in PMC

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