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. 2021 Apr;184(4):770-772.
doi: 10.1111/bjd.19684. Epub 2020 Dec 28.

Secukinumab for the treatment of SAM syndrome associated with desmoglein-1 deficiency

L H Frommherz  1 , C M Schempp  1 , C Has  1
Affiliations

Secukinumab for the treatment of SAM syndrome associated with desmoglein-1 deficiency

L H Frommherz et al. Br J Dermatol. 2021 Apr.
No abstract available

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References

    1. Samuelov L, Sarig O, Harmon RM et al. Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. Nat Genet 2013; 45:1244-8.
    1. Taiber S, Samuelov L, Mohamad J et al. SAM syndrome is characterized by extensive phenotypic heterogeneity. Exp Dermatol 2018; 27:787-90.
    1. Has C, Jakob T, He Y et al. Loss of desmoglein 1 associated with palmoplantar keratoderma, dermatitis and multiple allergies. Br J Dermatol 2015; 172:257-61.
    1. McAleer MA, Pohler E, Smith FJD et al. Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. J Allergy Clin Immunol 2015; 136:1268-76.
    1. Hernández-Martín A, Kennedy-Batalla R, Cañedo E et al. Imbalance in T-Helper 17 Cells and targeted therapy in an infant with SAM-like syndrome. N Engl J Med 2019; 381:2176-8.

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