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Editorial
. 2021 Feb;8(1):171-174.
doi: 10.1002/ehf2.13078. Epub 2020 Nov 17.

Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019

Gábor Tamás Szabó  1 , Attila Kiss  2 , Zoltán Csanádi  1 , Dániel Czuriga  1
Affiliations
Editorial

Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019

Gábor Tamás Szabó et al. ESC Heart Fail. 2021 Feb.
No abstract available

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Pathological changes in signalling pathways leading to hypothetical ENaC dysfunction and electrolyte disturbances in COVID‐19. ACE1, angiotensin‐converting enzyme 1; ACE2, angiotensin‐converting enzyme 2; ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin II receptor blocker; AT1, angiotensin II receptor type 1; ATP, adenosine triphosphate; ENaC, epithelial sodium channel; Na+/K+, sodium–potassium ATPase; PAR‐1, protease‐activated receptor 1; S1, spike protein subunit 1; S2, spike protein subunit 2; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2; TGN, trans‐Golgi network; TMPRSS2, transmembrane protease serine 2.
See this image and copyright information in PMC

References

    1. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli‐Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Kreutz R, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes I. COVID‐19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res 2020; 116: 1666–1687. - PMC - PubMed
    1. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS‐CoV‐2 spike glycoprotein. Cell 2020; 181: 281–292 e6. - PMC - PubMed
    1. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single‐cell RNA‐seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019‐nCoV infection. Front Med 2020; 14: 185–192. - PMC - PubMed
    1. Mamenko M, Zaika O, Pochynyuk O. Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling. Curr Opin Nephrol Hypertens 2014; 23: 122–129. - PMC - PubMed
    1. Sommerstein R, Kochen MM, Messerli FH, Gräni C. Coronavirus disease 2019 (COVID‐19): do angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers have a biphasic effect? J Am Heart Assoc 2020; 9: e016509. - PMC - PubMed

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