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Review
. 2020 Dec;17(12):e2000562.
doi: 10.1002/cbdv.202000562. Epub 2020 Nov 18.

Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019

Silei Lu  1 , Jiangming Wang  1 , Ruilong Sheng  2 , Yiwen Fang  3 , Ruihua Guo  1   4   5
Affiliations
Review

Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019

Silei Lu et al. Chem Biodivers. 2020 Dec.

Abstract

Marine organism-associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine-based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well. We expected that this review would be helpful for future in-depth research and development of marine-based bioactive polyketides.

Keywords: bioactivities; marine actinomycetes; polyketides; secondary metabolites; species distribution.

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References

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