Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Nov 13:54:e20200066.
doi: 10.1590/0037-8682-0066-2020. eCollection 2020.

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Gemilson Soares Pontes  1   2 , Hygor Halyson Figueiredo Ribeiro  2 , Diana Mota Toro  3 , José Pereira de Moura Neto  2   3 , Victor Souza  4 , Maria Edilene Martins de Almeida  4 , Valdinete Alves do Nascimento  4 , Cristovão Alves da Costa  1 , Felipe Gomes Naveca  4 , Mike Santos  5 , Antonio Carlos Rosário Vallinoto  5
Affiliations
Case Reports

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Gemilson Soares Pontes et al. Rev Soc Bras Med Trop. .

Abstract

Introduction: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.

Methods: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.

Results: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype.

Conclusions: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: There are no conflicts of interest in the present study for any of the authors.

Figures

FIGURE 1:
FIGURE 1:. Frequency of blood transfusions of study subjects according to their hematological disease. ITP: idiopathic thrombocytopenic purpura; SCD: sickle cell disease.
FIGURE 2:
FIGURE 2:. Phylogenetic tree showing the genetic similarity between the 5’ LTR region aligned sequence (611pb) of the HTLV-2 strain isolated in this study, and the sequences of 48 strains from the Genbank database. The tree was constructed using the neighbor-joining method and a bootstrap of 1,000 replicates. The branch of the isolated sample (JLM151) is labeled by a red dot.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Kalyanaraman VS, Sarngadharan MG, Robert-Guroff M, Miyoshi I, Blayney D, Golde D, et al. A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science. 1982;218(4572):571–573. - PubMed
    1. Murphy EL, Cassar O, Gessain A. Estimating the number of HTLV-2 infected persons in the world. Retrovirology. 2015;12(S1):05–05.
    1. Ferrer JF, Del Pino N, Esteban E, Sherman MP, Dube S, Dube DK, et al. High Rate of Infection with the Human T-Cell Leukemia Retrovirus Type II in Four Indian Populations of Argentina. Virology. 1993;197(2):576–584. - PubMed
    1. Lowis GW, Sheremata WA, Wickman PR, Dube S, Dube DK, Poiesz BJ. HTLV-II risk factors in native Americans in Florida. Neuroepidemiology. 1999;18(1):37–47. - PubMed
    1. Ishak R, Harrington WJ, Azevedo VN, Eiraku N, Ishak MOG, Guerreiro JF, et al. Identification of Human T Cell Lymphotropic Virus Type IIa Infection in the Kayapo, an Indigenous Population of Brazil. AIDS Res Hum Retroviruses. 1995;11(7):813–821. - PubMed

Publication types