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Case Reports
. 2020 Nov 13:54:e20200066.
doi: 10.1590/0037-8682-0066-2020. eCollection 2020.

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Gemilson Soares Pontes  1   2 , Hygor Halyson Figueiredo Ribeiro  2 , Diana Mota Toro  3 , José Pereira de Moura Neto  2   3 , Victor Souza  4 , Maria Edilene Martins de Almeida  4 , Valdinete Alves do Nascimento  4 , Cristovão Alves da Costa  1 , Felipe Gomes Naveca  4 , Mike Santos  5 , Antonio Carlos Rosário Vallinoto  5
Affiliations
Case Reports

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Gemilson Soares Pontes et al. Rev Soc Bras Med Trop. .

Abstract

Introduction: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.

Methods: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.

Results: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype.

Conclusions: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

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Conflict of interest statement

Conflicts of Interest: There are no conflicts of interest in the present study for any of the authors.

Figures

FIGURE 1:
FIGURE 1:. Frequency of blood transfusions of study subjects according to their hematological disease. ITP: idiopathic thrombocytopenic purpura; SCD: sickle cell disease.
FIGURE 2:
FIGURE 2:. Phylogenetic tree showing the genetic similarity between the 5’ LTR region aligned sequence (611pb) of the HTLV-2 strain isolated in this study, and the sequences of 48 strains from the Genbank database. The tree was constructed using the neighbor-joining method and a bootstrap of 1,000 replicates. The branch of the isolated sample (JLM151) is labeled by a red dot.
See this image and copyright information in PMC

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