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. 2021 Feb 24;223(4):562-567.
doi: 10.1093/infdis/jiaa724.

Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

Anne-Sophie Bedin  1 , Alain Makinson  2   3 , Marie-Christine Picot  4   5 , Frank Mennechet  1 , Fabrice Malergue  6 , Amandine Pisoni  1   7 , Esperance Nyiramigisha  7 , Lise Montagnier  7 , Karine Bollore  1 , Ségolène Debiesse  1 , David Morquin  3 , Nicolas Veyrenche  7 , Constance Renault  1 , Vincent Foulongne  1   7 , Caroline Bret  8 , Arnaud Bourdin  9   10 , Vincent Le Moing  2   3 , Philippe Van de Perre  1   7 , Edouard Tuaillon  1   7
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Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

Anne-Sophie Bedin et al. J Infect Dis. .

Erratum in

Abstract

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

Keywords: CD169; COVID-19; SARS-CoV-2; monocytes; viral infections.

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