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Comment
. 2020 Nov 17;53(5):897-899.
doi: 10.1016/j.immuni.2020.10.016.

The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge

Paras Singh Minhas  1 , Aarooran Sivakumaran Durairaj  1 , Katrin I Andreasson  2
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The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge

Paras Singh Minhas et al. Immunity. .
Free article

Abstract

The molecular mechanisms that restore microglial quiescence after acute stimulation remain largely unexplored, unlike those that drive microglial activation. In this issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglial quiescence after peripheral endotoxin challenge.

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