[Multivariate analysis of biological markers of excessive consumption of alcohol. Value of lipoprotein parameters]

Abstract

In order to investigate the usefulness of lipid, lipoprotein and apolipoprotein parameters for detection of intemperate drinkers, 90 adult male subjects with an alcohol consumption above 400 g weekly were compared to 90 matched (age, body weight index) male subjects with an alcohol consumption below 250 g weekly. GGT and MCV were also evaluated. Univariate analysis showed GGT, apolipoprotein A-II and phospholipid-LP no B levels to be parameters the most significantly different between drinkers and controls. Discriminant analysis using six parameters in addition to apolipoprotein A-II allowed to classify correctly 80% of subjects (efficacy) with respect to their alcohol consumption. However, sensitivity of the parameters remains relatively low and a good efficacy is obtained only with a composite index of several parameters.