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. 2020 Oct;11(5):836-846.
doi: 10.21037/jgo-20-193.

Factors associated with worse outcomes for colorectal neuroendocrine tumors in radical versus local resections

Osayande Osagiede  1 , Elizabeth Habermann  2 , Courtney Day  2 , Emmanuel Gabriel  3 , Amit Merchea  3 , Riccardo Lemini  3 , Iktej S Jabbal  3 , Dorin T Colibaseanu  3
Affiliations

Factors associated with worse outcomes for colorectal neuroendocrine tumors in radical versus local resections

Osayande Osagiede et al. J Gastrointest Oncol. 2020 Oct.

Abstract

Background: Colorectal neuroendocrine tumors (NETs) are the most common NETs of the gastrointestinal tract. Due to the rarity, colorectal NETs are understudied and are not clearly understood. Our study sought to identify the factors associated with worse outcomes for colorectal NETs following resection.

Methods: We identified patients diagnosed with colorectal NETs [2004-2014] who underwent resection from the National Cancer Data Base. Non-NETs were excluded. Overall survival (OS) was evaluated using the Kaplan Meier method. Cox proportional hazards and logistic regression models were used to assess factors associated with radical versus local resection, OS and LOS.

Results: A total of 7,967 colon and 11,929 rectal NETs were analyzed. The majority of colon (93.4%) and rectal (89.1%) NETs underwent radical and local resection respectively. The 5-year OS was 69% and 92% for colon and rectal NETs respectively. Older age (OR 1.45, CI 1.37-1.53) and clinical stage 4 (OR 9.91, CI 4.56-21.52) were associated with higher odds for colonic radical resection. Lowest median income quartile (OR 1.41, CI 1.21-1.64) and African Americans (OR 1.26, CI 1.07-1.49) experienced higher mortality for colon and rectal NETs respectively.

Conclusions: Racial minority and low-income patients experience worse outcomes for colorectal NETs following resection.

Keywords: National Cancer Data Base; Neuroendocrine neoplasms; colorectal cancer; endoscopic resection; neuroendocrine carcinoma (NEC); neuroendocrine tumors (NETs); outcomes; radical resection.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICJME uniform disclosure form (available at: http://dx.doi.org/10.21037/jgo-20-193). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
(A) Flow chart of inclusion/exclusion criteria among colon cancer cases. (B) Flow chart of inclusion/exclusion criteria among rectal cancer case.
Figure 2
Figure 2
Overall survival for colorectal NETs.
See this image and copyright information in PMC

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