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. 2020 Oct;9(5):636-644.
doi: 10.21037/tp-20-216.

Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

Wenjun Wang  1 , Xiumei Du  1 , Lu Ye  1 , Xiaoli Wang  1 , Guoyun Zhang  1
Affiliations

Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

Wenjun Wang et al. Transl Pediatr. 2020 Oct.

Abstract

Background: Allergic conjunctivitis (AC) is predominantly caused by serum specific-IgE (sIgE)-mediated type I allergy. This study aims to analyze the distribution of sIgE in children with AC, and the concomitant allergic diseases.

Methods: The clinical data from 310 children, diagnosed with AC and admitted to our hospital from January 2017 to January 2019 were retrospectively collected. The children were divided into three groups: infant group (2 months to 1 year old, 91 cases), child group (1 to 3 years old, 112 cases), and preschool group (3 to 6 years old, 107 cases). Children in every group were analyzed for positive rates, the number of positive sIgE types, the distribution of positive inhaling and ingesting allergens and concomitant allergic diseases.

Results: The sIgE positive rate of infant was significantly lower than that of the other two groups, and the number of 18.75% sIgE positive species was 1. The number of sIgE positive species in the child group and preschool group was more than 2 (78.30%, 71.15%). The positive rate of sIgE to dust mites, house dust, animal dander, eggs, beef, mutton and mango in the preschool group was significantly higher than the other groups (P<0.05). The positive rate of sIgE to milk in infant group was significantly higher than the other two groups (P<0.05). Children in the preschool group showed the highest incidence of AC, AC + allergic rhinitis, AC + allergic rhinitis + wheezing, while those in the infant group displayed the lowest incidence (P<0.05). AC + gastrointestinal allergy, AC + atopic dermatitis, AC + gastrointestinal allergy + atopic dermatitis in infant group was significantly higher than the other two groups (P<0.05). Patients in the child group displayed a significantly higher incidence of AC + infant wheezing than the other two groups (P<0.05).

Conclusions: We correlated children's age with the positive rate and gradual increase in types of AC allergens. Concomitant allergic diseases of children with AC at different ages conform to the natural course of allergic diseases. In clinic, improving the diagnostic efficiency of AC in children, and early interventional treatment will positively contribute to their prognosis, and reduce the risk of other allergic diseases.

Keywords: Allergic conjunctivitis in children (AC in children); concomitant allergic disease; serum-specific IgE (sIgE).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tp-20-216). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The positive distribution of inhaled allergen total IgE and sIgE in the three groups.
Figure 2
Figure 2
The positive distribution of total IgE and sIgE of allergen ingestion in children with AC in three groups. AC, allergic conjunctivitis.
Figure 3
Figure 3
Distribution of other allergic diseases in children of different groups.
See this image and copyright information in PMC

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