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. 2021 Feb;89(2):408-413.
doi: 10.1002/ana.25957. Epub 2020 Nov 30.

Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease

Giulia Fadda  1 , Brenda Banwell  1   2 , Patrick Waters  3 , Ruth A Marrie  4 , E Ann Yeh  5 , Julia O'Mahony  6 , Douglas A Arnold  7 , Amit Bar-Or  1   2   7 ; Canadian Pediatric Demyelinating Disease Network
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Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease

Giulia Fadda et al. Ann Neurol. 2021 Feb.

Abstract

Anti-myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) antibodies are associated clinically with either a monophasic or relapsing disease course. We investigated the frequency and clinical importance of acquired asymptomatic brain magnetic resonance imaging (MRI) lesions in a prospective incident cohort of 74 MOG-IgG positive children with serial MRI scans over a median of 5 years from presentation. Silent new lesions were detected in 14% of MOG-IgG positive participants, most commonly within the first months post-onset, with a positive predictive value for clinically relapsing disease of only 20%. Detection of asymptomatic lesions alone need not prompt initiation of chronic immunotherapy. ANN NEUROL 2021;89:408-413.

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References

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