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. 2020;75(S1):119-122.

[Neuropsychiatric complications of COVID-19]

[Article in French]
E Constant  1
Affiliations
  • PMID: 33211433
Free article

[Neuropsychiatric complications of COVID-19]

[Article in French]
E Constant. Rev Med Liege. 2020.
Free article

Abstract
in English, French

The COVID-19 coronavirus pandemic is a major stressor in the population, due to our physical vulnerability, our fear of dying, the major upheaval of our life habits linked to confinement and the difficulty of projecting us into the future. Caregivers themselves are more exposed than ever to burnout and post-traumatic stress disorder. However, other neuropsychiatric complications related directly to the viral infection of the central nervous system or secondary to the immune storm are to be feared in the short term (encephalopathies, myopathies, anosmia, ageusia) but also in the medium and long term (depression, anxiety disorders, schizophrenia, post-traumatic stress disorder, Guillain-Barre syndrome, Parkinson's disease or neurodegenerative conditions). The pathophysiological mechanisms, in particular immune mechanisms at the origin of the central nervous system damage, will be discussed. A strict longitudinal monitoring of these neuropsychiatric complications across all ages of the population is therefore necessary from now.

La pandémie à coronavirus COVID-19 constitue un facteur de stress majeur dans la population, de par la confrontation à notre vulnérabilité sur le plan physique, notre peur de mourir, le bousculement important de nos habitudes de vie liées au confinement et la difficulté de nous projeter dans le futur. Les soignants eux-mêmes sont, plus que jamais, exposés au burnout et au stress post-traumatique. Cependant, d’autres complications neuropsychiatriques en lien direct avec l’infection virale du système nerveux central ou secondaires à la tempête immunitaire sont à craindre à court terme (encéphalopathies, myopathies, anosmie, agueusie), mais aussi à moyen et long termes (dépression, troubles anxieux, schizophrénie, syndrome de stress post-traumatique, syndrome de Guillain-Barré, maladie de Parkinson ou affections neurodégénératives). Les mécanismes physiopathologiques, en particulier immunitaires, à l’origine de l’atteinte du système nerveux central, seront discutés. Un monitoring strict longitudinal de ces complications.

Keywords: COVID-19; Encephalopathy – Neurodegeneration; Immunity; Neuropsychiatry.

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