doi: 10.1007/BF00355492.
Carcinogenicity of trichloroethylene: fact or artifact?
- PMID: 332116
- DOI: 10.1007/BF00355492
Item in Clipboard
Carcinogenicity of trichloroethylene: fact or artifact?
Arch Toxicol.
.
Abstract
Technical trichloroethylene has been found carcinogenic in mice after high daily doses per os. A GC-MS analysis of this technical sample revealed the presence of considerable amounts of epichlorohydrin and 1.2-epoxibutane as stabilizers. These epoxides are highly mutagenic in the Ames test and are, most probably, responsible for the carcinogenic effect found in mice. The question whether trichloroethylene is carcinogenic or not remains open.
Similar articles
-
In vivo and in vitro mutagenicity studies of a possible carcinogen, trichloroethylene, and its two stabilizers, epichlorohydrin and 1,2-epoxybutane.Teratog Carcinog Mutagen. 1983;3(1):75-87. doi: 10.1002/1520-6866(1990)3:1<75::aid-tcm1770030109>3.0.co;2-5. Teratog Carcinog Mutagen. 1983. PMID: 6132459
-
Mutagenic activity of vinyl compounds and derived epoxides.Mutat Res. 1980 Jul;78(3):227-31. doi: 10.1016/0165-1218(80)90103-2. Mutat Res. 1980. PMID: 7001215
-
Detection of mutagenic impurities in carcinogens and noncarcinogens by high-pressure liquid chromatography and the Salmonella/microsome test.Cancer Res. 1978 Feb;38(2):431-8. Cancer Res. 1978. PMID: 340030
-
Comparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicals.Mutat Res. 1993 Mar;286(1):75-100. doi: 10.1016/0027-5107(93)90004-y. Mutat Res. 1993. PMID: 7678909 Review.
-
Chemical characterization of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhimurium system.Cancer Res. 1979 Sep;39(9):3289-318. Cancer Res. 1979. PMID: 383284 Review.
Cited by
-
Carcinogenicity study of trichloroethylene, with and without epoxide stabilizers, in mice.J Cancer Res Clin Oncol. 1984;107(3):149-56. doi: 10.1007/BF01032599. J Cancer Res Clin Oncol. 1984. PMID: 6736101 Free PMC article.
-
Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.J Cancer Res Clin Oncol. 1979 Jun 8;94(2):139-47. doi: 10.1007/BF00422494. J Cancer Res Clin Oncol. 1979. PMID: 157359
-
Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.Arch Toxicol. 1979 Feb 23;41(4):249-77. doi: 10.1007/BF00296896. Arch Toxicol. 1979. PMID: 373707 No abstract available.
-
Mortality in an european cohort occupationally exposed to epichlorohydrin (ECH).Int Arch Occup Environ Health. 1983;51(4):325-36. doi: 10.1007/BF00378345. Int Arch Occup Environ Health. 1983. PMID: 6862645
-
Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions.Cell Biol Toxicol. 1985 Jun;1(3):159-79. doi: 10.1007/BF00120162. Cell Biol Toxicol. 1985. PMID: 3917197
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
