Next-Generation Sequencing in Tumor Diagnosis and Treatment
- PMID: 33212911
- PMCID: PMC7698429
- DOI: 10.3390/diagnostics10110962
Next-Generation Sequencing in Tumor Diagnosis and Treatment
Abstract
Next-Generation Sequencing (NGS) allows for the sequencing of multiple genes at a very high depth of coverage [...].
Conflict of interest statement
Matteo Fassan received research grants from Astellas Pharma and QED (Quod Erat Demonstrandum) Therapeutics and reports personal fees (as a speaker or advisor to Astellas Pharma, GlaxoSmithKline (GSK), Diaceutics and Tesaro), which are unrelated to the current work. Umberto Malapelle reports personal fees (as a speaker or advisor) from Boehringer Ingelheim, AstraZeneca, Roche, MSD (Merck Sharp & Dohme), Amgen and Merck, Diaceutics and Eli Lilly, which are unrelated to the current work.
Similar articles
-
Standardization of Sequencing Coverage Depth in NGS: Recommendation for Detection of Clonal and Subclonal Mutations in Cancer Diagnostics.Front Oncol. 2019 Sep 4;9:851. doi: 10.3389/fonc.2019.00851. eCollection 2019. Front Oncol. 2019. PMID: 31552176 Free PMC article.
-
Special Issue: Next-Generation Sequencing in Tumor Diagnosis and Treatment II.Diagnostics (Basel). 2022 Aug 20;12(8):2017. doi: 10.3390/diagnostics12082017. Diagnostics (Basel). 2022. PMID: 36010367 Free PMC article.
-
Next-generation sequencing of custom amplicons to improve coverage of HaloPlex multigene panels.Biotechniques. 2014 Oct 1;57(4):204-7. doi: 10.2144/000114217. eCollection 2014 Oct. Biotechniques. 2014. PMID: 25312090
-
Next Generation Sequencing Data and Proteogenomics.Adv Exp Med Biol. 2016;926:11-19. doi: 10.1007/978-3-319-42316-6_2. Adv Exp Med Biol. 2016. PMID: 27686803 Review.
-
Next-generation sequencing: advances and applications in cancer diagnosis.Onco Targets Ther. 2016 Dec 2;9:7355-7365. doi: 10.2147/OTT.S99807. eCollection 2016. Onco Targets Ther. 2016. PMID: 27980425 Free PMC article. Review.
Cited by
-
Liquid Biopsy in Prostate Cancer Management-Current Challenges and Future Perspectives.Cancers (Basel). 2022 Jul 4;14(13):3272. doi: 10.3390/cancers14133272. Cancers (Basel). 2022. PMID: 35805043 Free PMC article. Review.
-
The Role of the Pathologist in the Next-Generation Era of Tumor Molecular Characterization.Diagnostics (Basel). 2021 Feb 18;11(2):339. doi: 10.3390/diagnostics11020339. Diagnostics (Basel). 2021. PMID: 33670699 Free PMC article. Review.
-
Next generation sequencing in cytology.Cytopathology. 2021 Sep;32(5):588-595. doi: 10.1111/cyt.12974. Epub 2021 Apr 1. Cytopathology. 2021. PMID: 33792981 Free PMC article. Review.
-
Next‑generation sequencing failure rates in rare tumors: A real‑world single‑institution analysis.Med Int (Lond). 2025 Mar 18;5(3):27. doi: 10.3892/mi.2025.226. eCollection 2025 May-Jun. Med Int (Lond). 2025. PMID: 40165794 Free PMC article.
-
Molecular alterations in pancreatic tumors.World J Gastroenterol. 2021 Jun 7;27(21):2710-2726. doi: 10.3748/wjg.v27.i21.2710. World J Gastroenterol. 2021. PMID: 34135550 Free PMC article. Review.
References
-
- Molnar C., Badon E.S., Mokanszki A., Monus A., Beke L., Gyory F., Nagy E., Mehes G. High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis. Diagnostics. 2020;10:48. doi: 10.3390/diagnostics10010048. - DOI - PMC - PubMed
-
- Chien Y.C., Mokanszki A., Huang H.Y., Geronimo Silva R., Jr., Chen C.C., Beke L., Monus A., Mehes G. First Glance of Molecular Profile of Atypical Cellular Angiofibroma/Cellular Angiofibroma with Sarcomatous Transformation by Next Generation Sequencing. Diagnostics. 2020;10:35. doi: 10.3390/diagnostics10010035. - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Medical