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Review
. 2020 Nov 17;9(11):2495.
doi: 10.3390/cells9112495.

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology

Cristine Alves da Costa  1 , Wejdane El Manaa  1 , Eric Duplan  1 , Frédéric Checler  1
Affiliations
Review

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology

Cristine Alves da Costa et al. Cells. .

Abstract

Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded protein response (UPR) has emerged as a key cellular dysfunction associated with the etiology of the disease. The UPR involves a coordinated response initiated in the endoplasmic reticulum that grants the correct folding of proteins. This review gives insights on the ER and its functioning; the UPR signaling cascades; and the link between ER stress, UPR activation, and physiopathology of PD. Thus, post-mortem studies and data obtained by either in vitro and in vivo pharmacological approaches or by genetic modulation of PD causative genes are described. Further, we discuss the relevance and impact of the UPR to sporadic and genetic PD pathology.

Keywords: Parkinson’s disease; genetics; reticulum endoplasmic; unfolded protein response.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The unfolded protein response (UPR) signaling pathways.
Figure 2
Figure 2
Evidence of the implication of UPR in Parkinson’s disease (PD) physiopathology demonstrated by post-mortem analysis and in vitro and in vivo pharmacological/genetic studies. Reference numbers are provided in brackets.
See this image and copyright information in PMC

References

    1. Baumann O., Walz B. Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int. Rev. Cytol. 2001;205:149–214. - PubMed
    1. Voeltz G.K., Rolls M.M., Rapoport T.A. Structural organization of the endoplasmic reticulum. EMBO Rep. 2002;3:944–950. doi: 10.1093/embo-reports/kvf202. - DOI - PMC - PubMed
    1. Shibata Y., Voeltz G.K., Rapoport T.A. Rough sheets and smooth tubules. Cell. 2006;126:435–439. doi: 10.1016/j.cell.2006.07.019. - DOI - PubMed
    1. Alberts B.J.A., Lewis J., Raff M., Roberts K., Walter P. Molecular Biology of the Cell. 4th ed. Garland Science; New York, NY, USA: 2002.
    1. Toulmay A., Prinz W.A. Lipid transfer and signaling at organelle contact sites: The tip of the iceberg. Curr. Opin. Cell Biol. 2011;23:458–463. doi: 10.1016/j.ceb.2011.04.006. - DOI - PMC - PubMed

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