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. 2020 Nov;25(46):2001815.
doi: 10.2807/1560-7917.ES.2020.25.46.2001815.

Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020

Sybille Welker  1 , Sébastien Boutin  2 , Thomas Miethke  1 , Klaus Heeg  2 , Dennis Nurjadi  2
Affiliations

Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020

Sybille Welker et al. Euro Surveill. 2020 Nov.

Abstract

The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be under-reported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

Keywords: Enterobacterales; Escherichia coli ST131; OXA-244; antimicrobial resistance; carbapenem resistance.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Antimicrobial resistance genes in OXA-244-producing Escherichia coli in the Rhine-Neckar region, Germany, 2019–2020 (n = 9)
Figure 2
Figure 2
Genetic characteristics of bla OXA-244-harbouring Escherichia coli in the Rhine-Neckar region, Germany, 2019–2020 (n = 9)
See this image and copyright information in PMC

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