Recent Administration of Iodinated Contrast Renders Core Infarct Estimation Inaccurate Using RAPID Software
- PMID: 33214184
- PMCID: PMC7963234
- DOI: 10.3174/ajnr.A6908
Recent Administration of Iodinated Contrast Renders Core Infarct Estimation Inaccurate Using RAPID Software
Abstract
Background and purpose: Automated CTP software is increasingly used for extended window emergent large-vessel occlusion to quantify core infarct. We aimed to assess whether RAPID software underestimates core infarct in patients with an extended window recently receiving IV iodinated contrast.
Materials and methods: We reviewed a prospective, single-center data base of 271 consecutive patients who underwent CTA ± CTP for acute ischemic stroke from May 2018 through January 2019. Patients with emergent large-vessel occlusion confirmed by CTA in the extended window (>6 hours since last known well) and CTP with RAPID postprocessing were included. Two blinded raters independently assessed CT ASPECTS on NCCT performed at the time of CTP. RAPID software used relative cerebral blood flow of <30% as a surrogate for irreversible core infarct. Patients were dichotomized on the basis of receiving recent IV iodinated contrast (<8 hours before CTP) for a separate imaging study.
Results: The recent IV contrast and contrast-naïve cohorts comprised 23 and 15 patients, respectively. Multivariate linear regression analysis demonstrated that recent IV contrast administration was independently associated with a decrease in the RAPID core infarct estimate (proportional increase = 0.34; 95% CI, 0.12-0.96; P = .04).
Conclusions: Patients who received IV iodinated contrast in proximity (<8 hours) to CTA/CTP as part of a separate imaging study had a much higher likelihood of core infarct underestimation with RAPID compared with contrast-naïve patients. Over-reliance on RAPID postprocessing for treatment disposition of patients with extended window emergent large-vessel occlusion should be avoided, particularly with recent IV contrast administration.
© 2020 by American Journal of Neuroradiology.
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Comment in
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Acute Stroke Imaging in Transfer Patients Who Received Recent Intravenous Iodinated Contrast at an Outside Facility: An Unrecognized Problem That Deserves More Attention.AJNR Am J Neuroradiol. 2021 Jun;42(6):E33. doi: 10.3174/ajnr.A7041. Epub 2021 Feb 25. AJNR Am J Neuroradiol. 2021. PMID: 33632739 Free PMC article. No abstract available.
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Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion Studies of Patients with Large-Vessel Occlusions?AJNR Am J Neuroradiol. 2021 Aug;42(8):E56-E57. doi: 10.3174/ajnr.A7139. Epub 2021 May 13. AJNR Am J Neuroradiol. 2021. PMID: 33985957 Free PMC article. No abstract available.
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Reply.AJNR Am J Neuroradiol. 2021 Aug;42(8):E58-E59. doi: 10.3174/ajnr.A7160. Epub 2021 May 13. AJNR Am J Neuroradiol. 2021. PMID: 33985958 Free PMC article. No abstract available.
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