. 2021 Mar 18;57(3):2001600.

doi: 10.1183/13993003.01600-2020. Print 2021 Mar.

Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals

Vânia Rocha^{1

2}, Sílvia Fraga^{1

3

2}, Carla Moreira^{1

4}, Cristian Carmeli⁵, Alexandra Lenoir⁶, Andrew Steptoe⁷, Graham Giles⁸, Marcel Goldberg^{9

10}, Marie Zins^{9

10}, Mika Kivimäki¹¹, Paolo Vineis¹², Peter Vollenweider¹³, Henrique Barros^{1

3}, Silvia Stringhini^{14

15}; LIFEPATH Consortium; members of the LIFEPATH Consortium (in alphabetical order):

Collaborators, Affiliations

Collaborators

Jan Alberts, Harri Alenius, Mauricio Avendano, Laura Baglietto, Valeria Baltar, Henrique Barros, Mel Bartley, Michele Bellone, Eloise Berger, David Blane, Murielle Bochud, Giulia Candiani, Cristian Carmeli, Luca Carra, Raphaele Castagne, Marc Chadeau-Hyam, Sergio Cima, Giuseppe Costa, Emilie Courtin, Cyrille Delpierre, Angelo D'Errico, Angela Donkin, Pierre-Antoine Dugue, Paul Elliott, Guy Fagherazzi, Giovanni Fiorito, Silvia Fraga, Martina Gandini, Valérie Gares, Pascale Gerbouin-Rerolle, Graham Giles, Marcel Goldberg, Dario Greco, Allison Hodge, Maryam Karimi, Piia Karisola, Michelle Kelly-Irving, Mika Kivimaki, Jessica Laine, Thierry Lang, Audrey Laurent, Richard Layte, Benoit Lepage, Dori Lorsch, Giles Machell, Johan Mackenbach, Michael Marmot, Cathal McCrory, Carlos de Mestral, Cynthia Miller, Roger Milne, Peter Muennig, Wilma Nusselder, Dusan Petrovic, Lourdes Pilapil, Silvia Polidoro, Martin Preisig, Ana Isabel Ribeiro, Fulvio Ricceri, Paolo Recalcati, Erica Reinhard, Oliver Robinson, Jose Rubio Valverde, Severine Saba, Frank Santegoets, Gianluca Severi, Terrence Simmons, Silvia Stringhini, Adam Tabak, Vesa Terhi, Joannie Tieulent, Salvatore Vaccarella, Federica Vigna-Taglianti, Paolo Vineis, Peter Vollenweider, Marie Zins

Affiliations

¹ EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
² These authors contributed equally.
³ Departamento de Ciências da Saúde Pública e Forenses, e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
⁴ Centre of Mathematics, University of Minho, Braga, Portugal.
⁵ Population Health Laboratory, Dept of Community Health, University of Fribourg, Fribourg, Switzerland.
⁶ Dept of Medicine, Respiratory Medicine, Lausanne University Hospital, Lausanne, Switzerland.
⁷ Dept of Behavioural Science and Health, University College London, London, UK.
⁸ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
⁹ Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
¹⁰ Paris Descartes University, Paris, France.
¹¹ Dept of Epidemiology and Public Health, University College London, London, UK.
¹² MRC Centre for Environment and Health, School of Public Health, Dept of Epidemiology and Biostatistics, Imperial College London, London, UK.
¹³ Dept of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
¹⁴ Center for Primary Care and Public Health (UNISANTE), University of Lausanne, Lausanne, Switzerland.
¹⁵ Unit of Population Epidemiology, Dept of Primary Care, Geneva University Hospitals, Geneva, Switzerland.

PMID: 33214206
DOI: 10.1183/13993003.01600-2020

Free article

Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals

Vânia Rocha et al. Eur Respir J. 2021.

Free article

. 2021 Mar 18;57(3):2001600.

doi: 10.1183/13993003.01600-2020. Print 2021 Mar.

Authors

Collaborators

Jan Alberts, Harri Alenius, Mauricio Avendano, Laura Baglietto, Valeria Baltar, Henrique Barros, Mel Bartley, Michele Bellone, Eloise Berger, David Blane, Murielle Bochud, Giulia Candiani, Cristian Carmeli, Luca Carra, Raphaele Castagne, Marc Chadeau-Hyam, Sergio Cima, Giuseppe Costa, Emilie Courtin, Cyrille Delpierre, Angelo D'Errico, Angela Donkin, Pierre-Antoine Dugue, Paul Elliott, Guy Fagherazzi, Giovanni Fiorito, Silvia Fraga, Martina Gandini, Valérie Gares, Pascale Gerbouin-Rerolle, Graham Giles, Marcel Goldberg, Dario Greco, Allison Hodge, Maryam Karimi, Piia Karisola, Michelle Kelly-Irving, Mika Kivimaki, Jessica Laine, Thierry Lang, Audrey Laurent, Richard Layte, Benoit Lepage, Dori Lorsch, Giles Machell, Johan Mackenbach, Michael Marmot, Cathal McCrory, Carlos de Mestral, Cynthia Miller, Roger Milne, Peter Muennig, Wilma Nusselder, Dusan Petrovic, Lourdes Pilapil, Silvia Polidoro, Martin Preisig, Ana Isabel Ribeiro, Fulvio Ricceri, Paolo Recalcati, Erica Reinhard, Oliver Robinson, Jose Rubio Valverde, Severine Saba, Frank Santegoets, Gianluca Severi, Terrence Simmons, Silvia Stringhini, Adam Tabak, Vesa Terhi, Joannie Tieulent, Salvatore Vaccarella, Federica Vigna-Taglianti, Paolo Vineis, Peter Vollenweider, Marie Zins

Affiliations

¹ EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
² These authors contributed equally.
³ Departamento de Ciências da Saúde Pública e Forenses, e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
⁴ Centre of Mathematics, University of Minho, Braga, Portugal.
⁵ Population Health Laboratory, Dept of Community Health, University of Fribourg, Fribourg, Switzerland.
⁶ Dept of Medicine, Respiratory Medicine, Lausanne University Hospital, Lausanne, Switzerland.
⁷ Dept of Behavioural Science and Health, University College London, London, UK.
⁸ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
⁹ Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
¹⁰ Paris Descartes University, Paris, France.
¹¹ Dept of Epidemiology and Public Health, University College London, London, UK.
¹² MRC Centre for Environment and Health, School of Public Health, Dept of Epidemiology and Biostatistics, Imperial College London, London, UK.
¹³ Dept of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
¹⁴ Center for Primary Care and Public Health (UNISANTE), University of Lausanne, Lausanne, Switzerland.
¹⁵ Unit of Population Epidemiology, Dept of Primary Care, Geneva University Hospitals, Geneva, Switzerland.

PMID: 33214206
DOI: 10.1183/13993003.01600-2020

Abstract

Background: Lung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to disadvantaged socioeconomic conditions across the life-course.

Methods: This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung function assessed by forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC). 70 496 participants (51% female) aged 18-93 years were included. Socioeconomic disadvantage was measured in early life (low paternal occupational position), early adulthood (low educational level) and adulthood (low occupational position). Risk factors for poor lung function (e.g. smoking, obesity, sedentary behaviour, cardiovascular and respiratory diseases) were included as potential mediators. The years of lung function lost due to socioeconomic disadvantage were computed at each life stage.

Results: Socioeconomic disadvantage during the life-course was associated with a lower FEV₁. By the age of 45 years, individuals experiencing disadvantaged socioeconomic conditions had lost 4-5 years of healthy lung function versus their more advantaged counterparts (low educational level -4.36 (95% CI -7.33--2.37) for males and -5.14 (-10.32--2.71) for females; low occupational position -5.62 (-7.98--4.90) for males and -4.32 (-13.31--2.27) for females), after accounting for the risk factors for lung function. By the ages of 65 years and 85 years, the years of lung function lost due to socioeconomic disadvantage decreased by 2-4 years, depending on the socioeconomic indicator. Sensitivity analysis using FVC yielded similar results to those using FEV₁.

Conclusion: Life-course socioeconomic disadvantage is associated with lower lung function and predicts a significant number of years of lung function loss in adulthood and at older ages.

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Conflict of interest statement

Conflict of interest: V. Rocha reports grants from Fundação para a Ciência e Tecnologia, during the conduct of the study. Conflict of interest: S. Fraga reports grants from Fundação para a Ciência e Tecnologia, during the conduct of the study. Conflict of interest: C. Moreira has nothing to disclose. Conflict of interest: C. Carmeli has nothing to disclose. Conflict of interest: A. Lenoir has nothing to disclose. Conflict of interest: A. Steptoe has nothing to disclose. Conflict of interest: G. Giles has nothing to disclose. Conflict of interest: M. Goldberg has nothing to disclose. Conflict of interest: M. Zins has nothing to disclose. Conflict of interest: M. Kivimäki reports grants from Medical Research Council, US National Institute on Aging, NordForsk, the Academy of Finland and Helsinki Institute of Life Science, during the conduct of the study. Conflict of interest: P. Vineis has nothing to disclose. Conflict of interest: P. Vollenweider has nothing to disclose. Conflict of interest: H. Barros has nothing to disclose. Conflict of interest: S. Stringhini reports grants from University of Lausanne, during the conduct of the study.

Comment in

Socioeconomic disadvantage and lung health: accumulating evidence to support health policy.
Stanojevic S. Stanojevic S. Eur Respir J. 2021 Mar 18;57(3):2004025. doi: 10.1183/13993003.04025-2020. Print 2021 Mar. Eur Respir J. 2021. PMID: 33737378 No abstract available.

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Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals

Collaborators

Affiliations

Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Comment in

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Grants and funding

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