Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 31;39(4):501-503.
doi: 10.23876/j.krcp.20.116.

Decline in platelet function following administration of a snake venom-derived hemocoagulase in a patient with end-stage renal disease

Byung Soo Kang  1 , Young Il Kim  1 , Sae-Yong Hong  1 , Seong Su Ban  2 , Won Seon Han  3 , Byung Geun Kim  4
Affiliations

Decline in platelet function following administration of a snake venom-derived hemocoagulase in a patient with end-stage renal disease

Byung Soo Kang et al. Kidney Res Clin Pract. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

All authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1. Sequential measurements of the platelet aggregation function test in case 1.
Botropase is initiated on two separate occasions. First, botropase 4 mL/day for three days after the surgery as usual. No platelet function test was performed during this period. Second, botropase initiated between hospitalization days 6 and 11 to treat gastric ulcer bleeding. The platelet function test was performed four times on hospitalization days 11, 12, 13, and 16. ADP, adenosine diphosphate; AUC, area under the aggregation curve; U, units.
Figure 2
Figure 2. Sequential measurements of the platelet aggregation function test in case 2.
The platelet function test was performed on hospitalization days 1, 3, 4, and 6. Botropase-mediated platelet dysfunction developed within three days after injection and recovered within two days after cessation. ADP, adenosine diphosphate; AUC, area under the aggregation curve; U, units.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Shenoy AK, Ramesh KV, Chowta MN, Adhikari PM, Rathnakar UP. Effects of botropase on clotting factors in healthy human volunteers. Perspect Clin Res. 2014;5:71–74. doi: 10.4103/2229-3485.128024. - DOI - PMC - PubMed
    1. Galbusera M, Remuzzi G, Boccardo P. Treatment of bleeding in dialysis patients. Semin Dial. 2009;22:279–286. doi: 10.1111/j.1525-139X.2008.00556.x. - DOI - PubMed
    1. Paniccia R, Priora R, Liotta AA, Abbate R. Platelet function tests: a comparative review. Vasc Health Risk Manag. 2015;11:133–148. doi: 10.2147/VHRM.S44469. - DOI - PMC - PubMed
    1. Vickers JD. Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin. Platelets. 1999;10:228–237. doi: 10.1080/09537109976077. - DOI - PubMed
    1. Sibbing D, Braun S, Morath T, et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol. 2009;53:849–856. doi: 10.1016/j.jacc.2008.11.030. - DOI - PubMed

LinkOut - more resources