Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 19;11(1):5900.
doi: 10.1038/s41467-020-19653-5.

15 years of genome-wide association studies and no signs of slowing down

Ruth J F Loos  1   2
Affiliations

15 years of genome-wide association studies and no signs of slowing down

Ruth J F Loos. Nat Commun. .

Abstract

Over the past 15 years, genome-wide association studies (GWASs) have generated a wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution genome-screens will continue to drive gene discovery in years ahead. Meanwhile, GWAS loci are increasingly translated into new biology and opportunities for clinical care.

PubMed Disclaimer

References

    1. Klein RJ, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385–389. doi: 10.1126/science.1109557. - DOI - PMC - PubMed
    1. The Wellcome Trust Case Control, C. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–678. doi: 10.1038/nature05911. - DOI - PMC - PubMed
    1. MacArthur J, et al. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) Nucleic Acids Res. 2017;45:D896–D901. doi: 10.1093/nar/gkw1133. - DOI - PMC - PubMed
    1. Zeggini E, Gloyn AL, Barton AC, Wain LV. Translational genomics and precision medicine: Moving from the lab to the clinic. Science. 2019;365:1409–1413. doi: 10.1126/science.aax4588. - DOI - PubMed
    1. Cano-Gamez E, Trynka G. From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases. Front. Genet. 2020;11:424. doi: 10.3389/fgene.2020.00424. - DOI - PMC - PubMed

Publication types