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Review
. 2020 Nov;21(7):525-530.
doi: 10.2174/1389202921999200417172817.

The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity

Arturo S Herrera  1 , Paola E Solís Arias  1 , María Del C A Esparza  1 , Luis F T Bernal  1 , Andrey D Bondarev  1 , Vladimir P Fisenko  1 , Vladimir N Chubarev  1 , Nina N Minyaeva  1 , Liudmila M Mikhaleva  1 , Vadim V Tarasov  1 , Siva G Somasundaram  1 , Cecil E Kirkland  1 , Gjumrakch Aliev  1
Affiliations
Review

The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity

Arturo S Herrera et al. Curr Genomics. 2020 Nov.

Abstract

Background: The ability of the human body to produce metabolic energy from light modifies fundamental concepts of biochemistry.

Objective: This review discusses the relationships between the long-accepted concept is that glucose has a unique dual role as an energy source and as the main source of carbon chains that are precursors of all organic matter. The capability of melanin to produce energy challenges this premise.

Methods: The prevalent biochemical concept, therefore, needs to be adjusted to incorporate a newly discovered state of Nature based on melanin's ability to dissociate water to produce energy and to re-form water from molecular hydrogen and oxygen.

Results and discussion: Our findings regarding the potential implication of QIAPI-1 as a melanin precursor that has bioenergetics capabilities.

Conclusion: Specifically, we reported its promising application as a means for treating retinopathy of prematurity (ROP). The instant report focuses on the long-term treatment medical effects of melanin in treating ROP.

Keywords: Melanin; energy; hydrogen; oxygen; prematurity; retina; retinopathy of prematurity.

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Figures

Fig. (1)
Fig. (1)
Hematoxylin & Eosin (H&E) stained histological section of human retina. (A) The yellow star indicates the photoreceptor layer, devoid of blood vessels. The orange arrows indicate two blood vessels between the outer plexiform and the ganglion cell layers. (B) The same area under the higher resolution. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
Fig. (2)
Fig. (2)
Changing the concentration of reactants by providing supplementary oxygen. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
Fig. (3)
Fig. (3)
Case study of a premature infant prescribed with QIAPI 1®. (A) The patient on the first days after hospitalization, QIAPI 1 is given at least six times daily in the dose of three drops per ounce since Day 1; (B) The Intensive Care Unit setting; (C) The initial condition of the patient was poor, requiring continuous treatment. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
Fig. (4)
Fig. (4)
Case study of a premature infant prescribed with QIAPI 1® (cont’d). (A) The patient at age 4, still undergoing continuous treatment with QIAPI 1®; (B) The patient at age 9, showing signs of normal physical and mental development. QIAPI 1® had been given at least four times daily since birth. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
See this image and copyright information in PMC

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