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Review
. 2020 Nov 16;182(47):V06200441.

[Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth]

[Article in Danish]
Affiliations
  • PMID: 33215580
Free article
Review

[Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth]

[Article in Danish]
Hanne Trap Wolf et al. Ugeskr Laeger. .
Free article

Abstract

Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.

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