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. 2021 Apr;50(4):333-344.
doi: 10.1111/jop.13139. Epub 2021 Jan 5.

The potential role of Photodynamic therapy in oral premalignant and malignant lesions: A systematic review

Antonio Romano  1 , Dario Di Stasio  1 , Enrica Gentile  1 , Massimo Petruzzi  2 , Rosario Serpico  1 , Alberta Lucchese  1
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The potential role of Photodynamic therapy in oral premalignant and malignant lesions: A systematic review

Antonio Romano et al. J Oral Pathol Med. 2021 Apr.

Abstract

Background: Photodynamic therapy (PDT) is considered as a valid treatment option in various branches of dentistry. This systematic review aims to evaluate the usefulness of PDT for treatment of oral premalignant and malignant lesions.

Methods: The MeSH terms "Photodynamic therapy" and "PDT," in combination with other terms, have been searched by three search engines (PubMed, ISI Web of Science, and the Cochrane Library), and a systematic review has been performed. The Population, Intervention, Comparison, Outcomes, and Study design (PICOS) has been applied as method to outline our study eligibility criteria. Risk of Bias in Non-randomized Studies of Intervention (ROBINS-I) has been performed too.

Results: Initial results were 1513. Definitely, 27 studies met our selection criteria.

Conclusions: Topical PDT is an easy to perform technique, well-tolerated treatment and it appears to be an effective method with encouraging achievements in the treatment of premalignant and malignant lesions of the soft tissues of the oral cavity; nevertheless more studies are required to integrate the up-to-date experience of this application.

Keywords: malignant lesions; oral; photodynamic therapy; premalignant lesions.

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