Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes

Koichi Yuki¹, Lifei Hou², Miho Shibamura-Fujiogi³, Sophia Koutsogiannaki⁴, Sulpicio G Soriano⁵

Affiliations

¹ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: koichi.yuki@childrens.harvard.edu.
² Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lifei.hou@childrens.harvard.edu.
³ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: miho.fujiogi@childrens.harvard.edu.
⁴ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sophia.koutsogiannki@childrens.harvard.edu.
⁵ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sulpicio.soriano@childrens.harvard.edu.

PMID: 33217544
PMCID: PMC7856197
DOI: 10.1016/j.clim.2020.108635

Review

Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes

Koichi Yuki et al. Clin Immunol. 2021 Jan.

. 2021 Jan:222:108635.

doi: 10.1016/j.clim.2020.108635. Epub 2020 Nov 17.

Authors

Koichi Yuki¹, Lifei Hou², Miho Shibamura-Fujiogi³, Sophia Koutsogiannaki⁴, Sulpicio G Soriano⁵

Affiliations

¹ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: koichi.yuki@childrens.harvard.edu.
² Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lifei.hou@childrens.harvard.edu.
³ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: miho.fujiogi@childrens.harvard.edu.
⁴ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sophia.koutsogiannki@childrens.harvard.edu.
⁵ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sulpicio.soriano@childrens.harvard.edu.

PMID: 33217544
PMCID: PMC7856197
DOI: 10.1016/j.clim.2020.108635

Abstract

A growing literature has shown that volatile anesthetics are promiscuous molecules targeting multiple molecules, some of which are critical for immunological functions. We focused on studies that delineated target molecules of volatile anesthetics on immune cells and summarized the effects of volatile anesthetics on immune functions. We also presented the perspectives of studying volatile anesthetics-mediated immunomodulation.

Keywords: Immunomodulation; Surgery; Volatile anesthetics.

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Conflict of interest statement

Conflict of Interest: None

Figures

**Figure 1.. Signaling cascade for neutrophil recruitment and the effect of volatile anesthetics**
(A) Lipid-chemokine interaction. LTB₄ is released from injured tissues (left) and attracts neutrophils. Neutrophils recruited to the tissues release chemokines, which further attract neutrophils in the blood vessel (right). (B) Signaling cascades activated by chemoattractants and the effect of volatile anesthetics.

**Figure 2.. Signaling cascade for neutrophil phagocytosis and microbial killing and the effect of volatile anesthetics**
Rap1 assists the crosstalk between Fc receptor (FcR) and Mac-1.

**Figure 3.. Signaling cascade for proinflammatory cytokine production by neutrophils and the effect of volatile anesthetics**
Mac-1, TLR2 and TLR4 activation induces gene expression of cytokines and chemokines such as tumor necrosis factor (TNF)-α, IL1-β, IL-6, IL-12 and IFN-β.

See this image and copyright information in PMC

References

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1. Pinheiro CDS et al. Short-Term Regulation of FcgammaR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. Mediators Inflamm 2017, 2086840, doi:10.1155/2017/2086840 (2017). - DOI - PMC - PubMed
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Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes

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Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes

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