[BB creatine phosphokinase activity and content of the brain structures in senile dementia and Alzheimer's diseases]

Abstract

The creatine kinase (CPK) activity and content were determined in certain brain structures of patients with Alzheimer's disease and senile dementia and in the control group. The findings demonstrated the 5-10-fold decrease of CPK activity in the majority of the investigated brain areas and a 30-fold decrease in the occipital gyrus. The activity decrease did not depend on postmortal interval, sex and age. The content of CPK was increased in the same structures (130% of the control level). So an elevation in CPK values appears to compensate for the fall in CPK activity. Such phenomena can lead to different disturbances in energy metabolism of the brain in mental patients.