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Review
. 2020 Nov 18;21(22):8706.
doi: 10.3390/ijms21228706.

A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases

Albino Carrizzo  1   2 , Carmine Izzo  2 , Maurizio Forte  1 , Eduardo Sommella  3 , Paola Di Pietro  2 , Eleonora Venturini  1 , Michele Ciccarelli  2 , Gennaro Galasso  2 , Speranza Rubattu  1   4 , Petro Campiglia  2 , Sebastiano Sciarretta  1   5 , Giacomo Frati  1   5 , Carmine Vecchione  1   2
Affiliations
Review

A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases

Albino Carrizzo et al. Int J Mol Sci. .

Abstract

Cardiovascular diseases (CVDs) such as hypertension, atherosclerosis, myocardial infarction, and diabetes are a significant public health problem worldwide. Although several novel pharmacological treatments to reduce the progression of CVDs have been discovered during the last 20 years, the better way to contain the onset of CVDs remains prevention. In this regard, nutraceuticals seem to own a great potential in maintaining human health, exerting important protective cardiovascular effects. In the last years, there has been increased focus on identifying natural compounds with cardiovascular health-promoting effects and also to characterize the molecular mechanisms involved. Although many review articles have focused on the individual natural compound impact on cardiovascular diseases, the aim of this manuscript was to examine the role of the most studied nutraceuticals, such as resveratrol, cocoa, quercetin, curcumin, brassica, berberine and Spirulina platensis, on different CVDs.

Keywords: CVDs; Spirulina platensis; berberine; brassica; cocoa; curcumin; quercetin; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summary of the main molecular and physiological effects exerted by resveratrol, cocoa, quercetin, curcumin, brassica, berberine, and Spirulina platensis in hypertension. Red arrow (↓) indicates downregulation; black arrow (↑) indicates upregulation.
Figure 2
Figure 2
Summary of the main molecular and physiological effects exerted by resveratrol, cocoa, quercetin, curcumin, brassica, berberine, and Spirulina platensis in the atherosclerotic process. Red arrow (↓) indicates downregulation; black arrow (↑) indicates upregulation.
Figure 3
Figure 3
Summary of the main molecular and physiological effects exerted by resveratrol, cocoa, quercetin, curcumin, brassica, berberine, and Spirulina platensis in HF. Red arrow (↓) indicates downregulation; black arrow (↑) indicates upregulation.
Figure 4
Figure 4
Summary of the main molecular and physiological effects exerted by resveratrol, cocoa, quercetin, curcumin, brassica, berberine, and Spirulina platensis in diabetes. Red arrow (↓) indicates downregulation; black arrow (↑) indicates upregulation.
Figure 5
Figure 5
Schematic summary of the molecular effects of nutraceuticals in different CVDs.
See this image and copyright information in PMC

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