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Review
. 2021 Jan 29:538:125-131.
doi: 10.1016/j.bbrc.2020.11.021. Epub 2020 Nov 11.

COVID19- clinical presentation and therapeutic considerations

Grace Kenny  1 , Patrick W Mallon  2
Affiliations
Review

COVID19- clinical presentation and therapeutic considerations

Grace Kenny et al. Biochem Biophys Res Commun. .

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection.

Keywords: COVID-19; Clinical trials; Immunothearpies; SARS-CoV-2; Therapeutics.

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Conflict of interest statement

Declaration of competing interest P.M. has received honoraria and/or travel grants from Gilead Sciences, MSD, Bristol Myers Squibb and ViiV Healthcare.G.K. – no conflicts declared.

Figures

Fig. 1
Fig. 1
Timing of different therapeutic targets for COVID-19.
See this image and copyright information in PMC

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